Protein Info for GFF5239 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Chorismate synthase (EC 4.2.3.5)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00033: chorismate synthase
  • amino acids 10 to 348 (339 residues), 431.7 bits, E=9.5e-134
• PF01264: Chorismate_synt
  • amino acids 10 to 344 (335 residues), 424.1 bits, E=1.4e-131

Best Hits

Swiss-Prot: 83% identical to AROC_POLNA: Chorismate synthase (aroC) from Polaromonas naphthalenivorans (strain CJ2)

KEGG orthology group: K01736, chorismate synthase [EC: 4.2.3.5] (inferred from 84% identity to del:DelCs14_1894)

MetaCyc: 61% identical to chorismate synthase (Escherichia coli K-12 substr. MG1655)
Chorismate synthase. [EC: 4.2.3.5]

Predicted SEED Role

"Chorismate synthase (EC 4.2.3.5)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 4.2.3.5)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• superpathway of chorismate metabolism (43/59 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.3.5

Protein Sequence (366 amino acids)

>GFF5239 Chorismate synthase (EC 4.2.3.5) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MSGNTFGTLFRVTNFGESHGPAIGCVIDGCPPGMALSEADIQIELDRRRPGTSKFVTQRN
EPDAVEILSGVYEGKTTGTPIALLIRNTDQRSKDYGNILQTFRPGHADYTYWQKYGIRDP
RGGGRSSARLTAPTVAAGAVARKWLKERYGTTFRGHMTHVGELAIPFESWDHVPHNPFFA
PVADVSAIETYMNELRKSGDSCGARLRVTAQGMPVGLGQPLYDRLDADIAYAMLGLNAVK
GVEIGAGFASVAHRGSTHGDSLTPEGFKGNNAGGVLGGISTGQDLEVAIAIKPTSSILIP
RETIDTAGQPTEVITKGRHDPCVGIRATPIAEALLALVVMDHALLHRAQCGDVQLPTPDI
AAQARG