Protein Info for GFF5215 in Variovorax sp. SCN45

Annotation: Efflux ABC transporter, permease/ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 transmembrane" amino acids 39 to 57 (19 residues), see Phobius details amino acids 81 to 101 (21 residues), see Phobius details amino acids 164 to 185 (22 residues), see Phobius details amino acids 201 to 223 (23 residues), see Phobius details amino acids 288 to 308 (21 residues), see Phobius details PF06472: ABC_membrane_2" amino acids 25 to 311 (287 residues), 185.1 bits, see alignment E=2.7e-58 PF05992: SbmA_BacA" amino acids 34 to 361 (328 residues), 153.2 bits, see alignment E=1.9e-48 PF00005: ABC_tran" amino acids 398 to 528 (131 residues), 58.9 bits, see alignment E=1.4e-19

Best Hits

KEGG orthology group: K02471, putative ATP-binding cassette transporter (inferred from 79% identity to vpe:Varpa_1134)

Predicted SEED Role

"ABC transporter, fused ATPase and inner membrane subunits (EC 3.6.3.27)" (EC 3.6.3.27)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.27

Use Curated BLAST to search for 3.6.3.27

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (600 amino acids)

>GFF5215 Efflux ABC transporter, permease/ATP-binding protein (Variovorax sp. SCN45)
MSSSPSITARAGSFVQVLRRVFKLAAPYFQSEEKWRARAMLLTIVALNLFYVYVAVLGNE
WYGRFYDALQNKNAVVFWHEVGVFGWIAFANIAVQVLKFYVTQLLQLRWRTWMTRSYLSR
WMANRTFYHLELARYAGKDGHTPDNPDQRIQEDMQIFTSATMSLSMGLLNAVVTLMSFIG
LLWALSGNFSFTFHGVTHQIVGAMVWVALGYSVLGTVITHFVGRPLIGLNFRQQRFEADF
RHHLVRVREYSEAIALDHGEKVERDQLDLRFSNVLRNYLQLIKQQKNLVTFTSFFGQAAV
IFPFLVAGQQYFGGAFQLGHLMQIGSAFGKVQESLSWFVDNYDSVAVWRATTDRLTSFDD
SMTAHATQDDALQRAPAAVLHSDDLGVALPDGTPLLAGAALAVKPGDSVLLQGPSGSGKS
TLFRSFAGIWPFSKGRLQVPDNVAFMPQRPYVPDGKLRDALTYPNPATNFNDDQLRQALN
DALLPDLVNRLDESDAWSQKLSGGEQQRLAIARVLLKKPAWLFADEITSALDAQAESVLY
KRLAATVQAAGGAMVSIAHRAAVGDFHNQRWTMVPEAEGAATGGGPRYRLNTAAIQPAAA