Protein Info for GFF5185 in Sphingobium sp. HT1-2

Annotation: High-affinity Fe2+/Pb2+ permease precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 657 signal peptide" amino acids 1 to 42 (42 residues), see Phobius details transmembrane" amino acids 402 to 426 (25 residues), see Phobius details amino acids 438 to 461 (24 residues), see Phobius details amino acids 473 to 492 (20 residues), see Phobius details amino acids 516 to 541 (26 residues), see Phobius details amino acids 548 to 569 (22 residues), see Phobius details amino acids 580 to 601 (22 residues), see Phobius details amino acids 631 to 648 (18 residues), see Phobius details PF13442: Cytochrome_CBB3" amino acids 148 to 229 (82 residues), 41.7 bits, see alignment E=1.8e-14 PF00034: Cytochrom_C" amino acids 149 to 231 (83 residues), 45.8 bits, see alignment E=2e-15 PF03239: FTR1" amino acids 403 to 606 (204 residues), 78.9 bits, see alignment E=6.4e-26

Best Hits

KEGG orthology group: K07243, high-affinity iron transporter (inferred from 63% identity to cak:Caul_2302)

Predicted SEED Role

"High-affinity Fe2+/Pb2+ permease precursor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (657 amino acids)

>GFF5185 High-affinity Fe2+/Pb2+ permease precursor (Sphingobium sp. HT1-2)
MRLSFGPVRPCIRAVGKGCRYMFVLLLSAILSQIVPGQALASDTEVQTVWRLLDYVAVDY
AGAVSGGRVSSEAEYAEMVEFAGQVENRLGSLPDKSGKADLLRQTRALRAAIAAKAAPAG
VATQSKALASALLAAYPVPLAPTAPPVLARGSALYAQNCASCHGAAGDGHGPASAGLDPP
PIAFKDKVRADQRSLFGLYQVITQGLDGTAMAGFDSLPEQDRWALAFYVGTFAYPTSETG
HGQRLWHEDASLRQRYPNLAAFVGATPASLAAEIGPDKAEAVTAYLRRHPDMVTARANGS
LALTRERLDASLKAYAAGNRQAATDLALSAYLDGFEPVEPMLAAREPQLMARIEQAMGAL
RAAIGKARPLAEVQAANQELAGLFGEAEAALAPEKASSASSFLGAFGVLLREGLEALLIV
VAMIAFLRKTERTEVLGFVHGGWVAALAAGVASWFIATYFIGVSGASRELTEGFGSLFAA
IILLTVGIWMHGKSNAEAWQRYIKEKMTHALSKRSGWFLFLLAFIVVYREVFETILFYAA
LWAQGNGLAMLGGAAAAAVLLAMLAWIMLRYSTRLPITQFFSWSAILIAILAVVLAGKGI
AGLQEAGILGVVPLPGVPRIQMLGLFPTTETVLAQLIAVAILVAGFWLNRKSAVRTT