Protein Info for GFF5175 in Sphingobium sp. HT1-2

Annotation: CzcABC family efflux RND transporter, transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1039 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 335 to 353 (19 residues), see Phobius details amino acids 360 to 381 (22 residues), see Phobius details amino acids 387 to 406 (20 residues), see Phobius details amino acids 441 to 465 (25 residues), see Phobius details amino acids 472 to 497 (26 residues), see Phobius details amino acids 527 to 549 (23 residues), see Phobius details amino acids 859 to 876 (18 residues), see Phobius details amino acids 883 to 904 (22 residues), see Phobius details amino acids 910 to 931 (22 residues), see Phobius details amino acids 959 to 979 (21 residues), see Phobius details amino acids 991 to 1010 (20 residues), see Phobius details PF00873: ACR_tran" amino acids 7 to 1015 (1009 residues), 743.6 bits, see alignment E=3.4e-227 PF02355: SecD_SecF_C" amino acids 858 to 1010 (153 residues), 23.2 bits, see alignment E=4.2e-09

Best Hits

KEGG orthology group: None (inferred from 68% identity to neu:NE0669)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1039 amino acids)

>GFF5175 CzcABC family efflux RND transporter, transmembrane protein (Sphingobium sp. HT1-2)
MLAWLVRSALQQRVIVLVLAAILVVLGLRASTDVPLDVFPEFAPPIVEIQTEAPGLSTEE
VESLITVPIETQVNGVPGIATLRSKSVLGLSSVVLLLERGADVFRARQMVQERVTQAQAR
LPAAARPPIMLAPLSSTSRAMKIGISSKKLDQMELSELVRWTIRPRLMFVPGVANVAMWG
MRDRQLQVLVDPDKLRAAGVTLNELRLATGDAVLVGGGGFVDNANQRLAVQQPSAVQTAD
DLARTVVKLTGDAPIRVGDVARVTESYAAPIGNAIIDDGPGIMLIVEKQPTGNTLELTRS
VEAALEELKPGLQDVKVDSSIFRPATFIERSIDNLTRALAIGCFLVAVVLFLFTRDWRQA
IISLVAIPLSLLGAGLVLLWSGATINTMVIAGLVIALGEVVDDAIIDVENIARRLRLNRE
ADNPRTPFEVVLAASLEVRSAVVFASLIVMLVFLPIFFLGGVAGTFFQPLAIAYVLAIAA
SLLVALVVTPALCLFLLPNAPVKHEGDTRFVRALKGRYGAMLPRIIAAPRAVMIVIGAGL
LLAGVGYATFKDQFLPEFRETDFLMHWLEKPGASIEAMDRITIRVSKELRAIPGVRNFGA
HIGRAEAADEVVGPNFTELWISLDEKADYDGSVARIKEVIEGYPGLFRDVLTYLRERIKE
VLSGASATVVVRIFGPDQNELRAAADRIKQQVAGVEGVADLKVEQQVLVPQIRIRPRSGD
LATFGLTPGEVRRQAQSLVAGQKLGEIYRDQKAFDVALWGEAATRGDMHALADLMIQTPN
GGAVRLRDVADVAVVPAPNEIKREDGQRRLDVTLNVSGADLGTVAQAVESIVARTRFAQG
YHAKVLGEYAALKESRQRLWTTGLFCLVGILVLVWMEFRSHRITALVAVSLPFALVGGVV
AVAFTGSLLSLGSLVGFVTVIGIAARNGIMLLSHYHHLRVHEGEAFGPSLVLRGAEERLV
PILMTAACAGLALVPLIVAGNAPGHEIEHPMAIVILGGLVSSTLLNLFLMPALYARYGED
AAGPAEPSPQDARMKGAAI