Protein Info for PS417_26345 in Pseudomonas simiae WCS417

Annotation: choline dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 567 PF00732: GMC_oxred_N" amino acids 5 to 302 (298 residues), 196.8 bits, see alignment E=6.6e-62 TIGR01810: choline dehydrogenase" amino acids 6 to 539 (534 residues), 932.7 bits, see alignment E=3.2e-285 PF05199: GMC_oxred_C" amino acids 395 to 529 (135 residues), 140.4 bits, see alignment E=9.2e-45

Best Hits

Swiss-Prot: 98% identical to BETA_PSEFS: Oxygen-dependent choline dehydrogenase (betA) from Pseudomonas fluorescens (strain SBW25)

KEGG orthology group: K00108, choline dehydrogenase [EC: 1.1.99.1] (inferred from 98% identity to pfs:PFLU5686)

MetaCyc: 84% identical to choline dehydrogenase (Pseudomonas aeruginosa)
Choline dehydrogenase. [EC: 1.1.99.1]

Predicted SEED Role

"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.1

Use Curated BLAST to search for 1.1.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UDI2 at UniProt or InterPro

Protein Sequence (567 amino acids)

>PS417_26345 choline dehydrogenase (Pseudomonas simiae WCS417)
MSQEYDYIIVGAGSAGNTLATRLTEDEGVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGR
RYNWAYETDPEPHMDGRRMECGRGKGLGGSSLINGMCYIRGNAMDYDNWAKLPGLENWTY
LDCLPYFRKAETRDIGPNDWHGGDGPVSVTTPKAGNNPLFHAMVEAGVQAGYPRTEDLNG
YQQEGFGPMDRTVTPNGRRASTARGYLDTAKKRSTLTIVTHALTDKVLFEGKRAVGVRYL
IGAAEERVEARARKEVLVCSGAIASPQLLQRSGVGPAKLLESLDIPVVHDLPGVGENLQD
HLELYLQYACTQPVSLYPSLLWYNQPAIGAEWLFNGTGIGASNQFEAGGFIRTREEFEWP
NIQYHFLPVAINYNGSNGVKEHGFQAHMGSMRSPSRGRIQLKSKNPRDYPSILFNYMATE
QDWQEFRDGIRLTREIMQQPALDPYRGREISPGIDVQTDEQLDKFIREHAETAFHPSCSC
KMGTDEMAVVDGEGRVHGMQGLRVVDASIMPIITTGNLNAPTIMIAEKIADKIRGRQPLP
RSTADYYVAGDAPVRGKPMREVGPLAQ