Protein Info for GFF5129 in Sphingobium sp. HT1-2

Annotation: Cytochrome c oxidase polypeptide I (EC 1.9.3.1) / Cytochrome c oxidase polypeptide III (EC 1.9.3.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 840 transmembrane" amino acids 42 to 63 (22 residues), see Phobius details amino acids 89 to 112 (24 residues), see Phobius details amino acids 124 to 146 (23 residues), see Phobius details amino acids 170 to 194 (25 residues), see Phobius details amino acids 208 to 229 (22 residues), see Phobius details amino acids 261 to 284 (24 residues), see Phobius details amino acids 294 to 314 (21 residues), see Phobius details amino acids 326 to 353 (28 residues), see Phobius details amino acids 362 to 385 (24 residues), see Phobius details amino acids 398 to 421 (24 residues), see Phobius details amino acids 433 to 454 (22 residues), see Phobius details amino acids 478 to 500 (23 residues), see Phobius details amino acids 585 to 605 (21 residues), see Phobius details amino acids 611 to 630 (20 residues), see Phobius details amino acids 662 to 685 (24 residues), see Phobius details amino acids 705 to 724 (20 residues), see Phobius details amino acids 736 to 757 (22 residues), see Phobius details amino acids 772 to 796 (25 residues), see Phobius details amino acids 817 to 837 (21 residues), see Phobius details PF00115: COX1" amino acids 40 to 486 (447 residues), 466.5 bits, see alignment E=4.4e-144

Best Hits

KEGG orthology group: K02274, cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 64% identity to noc:Noc_1766)

Predicted SEED Role

"Cytochrome c oxidase polypeptide I (EC 1.9.3.1) / Cytochrome c oxidase polypeptide III (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (840 amino acids)

>GFF5129 Cytochrome c oxidase polypeptide I (EC 1.9.3.1) / Cytochrome c oxidase polypeptide III (EC 1.9.3.1) (Sphingobium sp. HT1-2)
MSLHDQDDPALRAAQEERLRAVWAPPRGIFLRWTDCNNNRVGVWYVLTAFGFMLFAGVLA
LIMRTQLAVPDNDLVGPGTFNQLFTLHGSMMMFLFAVPMFEAVSIILLPQLLGARDLPFP
RLSAFGYWSFLIGGLFVGGSIFFNAAPDGGWFMYPPLTTRTDLSGLGADIWMLGLSFIEV
SSVAAAVELIVGVLKCRPPGMRLNLMPLYAWYILVVAVMILFAFPPLIAGDILFEMERLL
DWPFFDARRGGDPLLWQHLFWIFGHPEVYIIFLPSIALFAMLVPTFANRHLLGYPWIVLA
AVGTAFLSFGLWVHHMFTTGLPKISLAFFSAASEAVAIPTGVQIFVFIATLWAGRVTWST
PLLYATGSLAIFVIGGLTGVMVAVAPFDWQAHDSYFIVAHLHYVLIGGTLMPLFAGLYYY
WPLVTGKKLSDRLGRVAFWMLFVGANLTFFPMHLSGLMGMPRRVFTYPAELGLGGLNMAS
TLGAWLFAAGVAVICVDLSLSPRRVRAVRNPWNAGTLEWLAHPEDEDWGIRSVPLIESRY
PIWDQTDFVRKVDEGRFFLPDAEEGRRETIVTSVLDARPLAVIRLGTPSIKPMLTAVALG
GVFILTTYHLYWAALVSGVATLAMALWWLWTGTAEIPEKPCKPIGHGLELPLYLSGPSAP
GWWAMFITMMADATAFSGLVFGYFFFWTRHADFPPVALADGPGMAWPMLALFLGIASWLL
TLGAREVHVRKHVGMARLCLMVALLLGLAGIGAGLAGPWTHGMDPQAHSYPAIVWTLAIW
AAAHAGVAAIMQGYALARSLAGRMDPVHDADLRNVTVYMHFYALTAIVTYATIGLFPQVT