Protein Info for GFF512 in Xanthobacter sp. DMC5

Annotation: Multidrug resistance protein MdtC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1052 signal peptide" amino acids 1 to 36 (36 residues), see Phobius details transmembrane" amino acids 336 to 352 (17 residues), see Phobius details amino acids 362 to 381 (20 residues), see Phobius details amino acids 388 to 410 (23 residues), see Phobius details amino acids 430 to 451 (22 residues), see Phobius details amino acids 462 to 485 (24 residues), see Phobius details amino acids 529 to 548 (20 residues), see Phobius details amino acids 862 to 880 (19 residues), see Phobius details amino acids 887 to 907 (21 residues), see Phobius details amino acids 913 to 934 (22 residues), see Phobius details amino acids 961 to 982 (22 residues), see Phobius details amino acids 990 to 1016 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 2 to 1016 (1015 residues), 1062.5 bits, see alignment E=0 PF03176: MMPL" amino acids 254 to 488 (235 residues), 32.6 bits, see alignment E=6.4e-12 PF02355: SecD_SecF_C" amino acids 336 to 478 (143 residues), 23.1 bits, see alignment E=6.5e-09

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 86% identity to xau:Xaut_4555)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1052 amino acids)

>GFF512 Multidrug resistance protein MdtC (Xanthobacter sp. DMC5)
MFSELCIRRPVMTTLIMLSLVVAGLFAYRQLPVAALPRVDFPTINISASLPGASPETMAT
SVATPIERQLATIAGISSLTSSSTQGSTSITVQFDLNRSIDAAALDVQSALSVAQRQLPD
EMTTPPSFRKVNPADAPVILLAISSDTLPLSAVNEYADTLIGQQISQLPGVAQVQIYGSQ
KYAVRIRVDPAAAGARNISADDIQRAVEAAASNTPLGIVSGPKQAQTIDMGTPKADASQF
RRVVVKARDGSVVRLEEIAVVSDGVENERVASWFNDRRAVVLAVVRQPDANTVQVVDEVR
NRLPQFRAQLPGSVGIEVLNDRSVSVRDAVADVQKTLFEAIVLVVLVIFLFLRNVRATII
PSLALPLSIIATFAAMWGFGYSINNMTLLALTLCVGFVVDDAIVVLENIYRHVEAGESPF
RAALRGSREIGFTIISMTLSLVAVFIPVLFMGGVVGRVFREFAVTISVAILVSGFVSLTL
TPMLCARVMKPVDHTKKPGWFFRVTERMFDSWLNAYRVSLDFVLRRKPFMLVVTFATIGL
SVYLYIVIPKGFFPQEDNGFITGTVEAATDSSFAAMVERQKQVADVVRADPAVDYIVSTA
GATGSSRTTNTGRLFIALKPKGNGPGERVGSANDVIQGLRKRVAQVPGVNVFFQPVQNIN
VGGVASKSQYQYTLQSPDTETLYAFAQTMEQRLAQLPGLRDVTSDLQITNPQLTIELDKD
KAAALGITEQQLRDALYTQFGTRQIATLYTPTNQFAIIAEVQPIFQRDPSDLGRVYLRTT
SGNVVPLETVANIKRTVGPLSIQHQQQQPSVTISFNLAPGTSLGQAVEEINAAAAEARVP
DSVIPGFQGTAQVFQDSLSNQPLLILAAVVVIYIVLGVLYESFIHPITILSGLPSAGIGA
LLTLMAAGMELSVIAIIGIIMLVGIVKKNAIMMIDVALERRRAGAAAQDAIREAALLRFR
PIMMTTLAAIFGVLPIAIGAGAGSELRQPLGVAVVGGLLVSQLLTLFITPVVYLYLDRLD
AIVHHAVSGRHEDKAHPAHPVPPVPPERMAAE