Protein Info for GFF5112 in Sphingobium sp. HT1-2

Annotation: Catalase KatE-intracellular protease (EC 1.11.1.6)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 714 PF00199: Catalase" amino acids 52 to 437 (386 residues), 593 bits, see alignment E=4.2e-182 PF06628: Catalase-rel" amino acids 474 to 537 (64 residues), 77 bits, see alignment E=1.5e-25 PF18011: Catalase_C" amino acids 571 to 691 (121 residues), 32.8 bits, see alignment E=7.7e-12

Best Hits

Swiss-Prot: 56% identical to CATE_RHIME: Catalase C (katE) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K03781, catalase [EC: 1.11.1.6] (inferred from 81% identity to nar:Saro_3563)

Predicted SEED Role

"Catalase (EC 1.11.1.6)" in subsystem Oxidative stress or Photorespiration (oxidative C2 cycle) (EC 1.11.1.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.6

Use Curated BLAST to search for 1.11.1.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (714 amino acids)

>GFF5112 Catalase KatE-intracellular protease (EC 1.11.1.6) (Sphingobium sp. HT1-2)
MTASGPKSDAALENSLADHRPGAGSPNYETTAGEGGETQQKLKAEQSGDALTDNFGHRIA
DNQNSLKAGARGPTLLEDFVLREKIFHFDHERIPERIVHARGSGAHGIFECTKAITDVTK
ASIFQKKGAHCPVFVRFSTVAGGAGSVDTPRDVRGFAVKFYTDTGNWDLVGNNIPVFFIQ
DAIKFPDLIHSVKMEADRGYPQAASAHDTFWDFVSLMPESMHMIMWAMSDRAIPRSLRMM
EGFGVHSFRFINEQGDGKFVKFHWKPVLGVASQVWDEAVKTAGADPDFHRRDLYEAIASG
DYPAWDLGVQIFDESWAAKQPYDVLDATKLIPEEDIPVEIIGRLTLNRNVDNFFAETEQV
AFLPSNVIPGIDFSNDPLLQGRLFSYLDTQKSRLGTTNFHQIPINAPKCPFHNMQRDGLM
QTLVPKGRANYEPNSLNEAGEDSGPRVASETGFTSFSDNGERNDPTEKMRIRAETFADHY
SQARMFYLSQTQNEQAHIASAIVFELSKVAMPHVRLRVLARLRNIDEVLAQRVADGLAIA
LPEKAPAAREIVEMPVSDALSIQKNAKDGFAGRKVGILFAEGSDKAMVEKIKAGVEKAGG
SVFLVAPKVGALNVKGGTLEADGKLDGSPSVLFDAIASVLMPESAEKLSKQGAAVQWFMD
AYGHCKTIAHCPGTQIILDKAGVEKDDGVIPNEMLLDKGPKRHWAREPKIRDLA