Protein Info for GFF511 in Xanthobacter sp. DMC5

Annotation: Multidrug resistance protein MdtA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 391 transmembrane" amino acids 20 to 37 (18 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 63 to 380 (318 residues), 248 bits, see alignment E=5.9e-78 PF16576: HlyD_D23" amino acids 74 to 298 (225 residues), 65.2 bits, see alignment E=7.9e-22 PF13533: Biotin_lipoyl_2" amino acids 84 to 131 (48 residues), 38.2 bits, see alignment 1.4e-13 PF13437: HlyD_3" amino acids 195 to 290 (96 residues), 37.9 bits, see alignment E=4e-13

Best Hits

KEGG orthology group: None (inferred from 79% identity to xau:Xaut_4556)

Predicted SEED Role

"Probable Co/Zn/Cd efflux system membrane fusion protein" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (391 amino acids)

>GFF511 Multidrug resistance protein MdtA (Xanthobacter sp. DMC5)
MPAENAPGSAKSGGSAGRKMVLAVLFLALLGGGAWVWDKKPWLAASGQKAAPPPRVVAVL
AGKAERTSLPVRVEALGTVESMVTVPVRSRVAAAVEKVGFADGATVKEGDLLYQLDPRVI
DAQILQAEATLNRDKVQLEKNLRDVERYAGLATRNAVSQVQVDDARTTADVQKAVVAQDE
ANLTALRVQRGYYEIRSPATGRIGVSSVRPGTVIRVDDTLATVRQLAPIYVAFGLPERYI
AGLRAAKDAKVSFTIQGTGETISGGTVAVIDNTIEPQTGTLTARAIFPNADERLWPGALG
AVTVTLRIEDNVVAVPSEAVQNGQDGPFVFIVDDGIAHVRPVTVTRTVDGRSVIAKGLDG
GETVVTDGQLSLREGSRVSVRTRTAVPATGS