Protein Info for GFF508 in Xanthobacter sp. DMC5

Annotation: K(+)/H(+) antiporter NhaP2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 592 transmembrane" amino acids 6 to 28 (23 residues), see Phobius details amino acids 35 to 54 (20 residues), see Phobius details amino acids 60 to 78 (19 residues), see Phobius details amino acids 90 to 113 (24 residues), see Phobius details amino acids 123 to 142 (20 residues), see Phobius details amino acids 198 to 216 (19 residues), see Phobius details amino acids 228 to 257 (30 residues), see Phobius details amino acids 267 to 293 (27 residues), see Phobius details amino acids 301 to 328 (28 residues), see Phobius details amino acids 337 to 359 (23 residues), see Phobius details amino acids 365 to 387 (23 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 19 to 386 (368 residues), 169.9 bits, see alignment E=8e-54 PF03471: CorC_HlyC" amino acids 494 to 563 (70 residues), 31.5 bits, see alignment E=1.4e-11

Best Hits

Swiss-Prot: 45% identical to NHAP2_VIBPA: K(+)/H(+) antiporter NhaP2 (nhaP2) from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

KEGG orthology group: K11105, cell volume regulation protein A (inferred from 87% identity to xau:Xaut_4559)

Predicted SEED Role

"Na+/H+ antiporter" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (592 amino acids)

>GFF508 K(+)/H(+) antiporter NhaP2 (Xanthobacter sp. DMC5)
MGSVVVSNIVLLVVAALVVVGTLSSLLAARFGAPILLVFLVVGVAAGEGGPGGIHFDDYW
ATYMVGSAALAVILFDGGLRMRVASMRGAILPAVGLSTVGVAFTAALVGLVAAPLLGLGW
MEALLVGAIVASTDAAAVLFLVRAQGLHLGRRVGSVIEIESATNDPAAVFLTVLLVELLT
SHLADPGLMVVFGALREMVVGAVLGVAGGYALVALLNRVDLPGGLHPVMVVGVAVLLFAL
TSLLHGSGFLAVYLAGLVVGNRPVRAIASITSFLDTITWLCQIVMFVMLGMLVSPEKILQ
YALPALGVAAFLILVGRPAAVFACLAPFHFSLKEKLFVSWAGLRGAVSIFLATIPMLAHL
PMAEVYFNVAFAVVLVSLILHGWTMAYAARRLDVALSDPDPGVRRFEIDLPGQTDMELVA
YPVMAATPAVGQAQLPPWARLVMVVRANETLTPEAAGPLKAGDYGYLLAPPKRVHQLDRM
FRPEETTPLDDSAAFPFVGEVRLGDLASFYGLAVPDSELGLTIADAFADRSDDQPAPGMR
IAYGHAVIEVRGVTDGRVTYAVLRLEAGRLKRSIARVRRLLGFPPEQDEDDE