Protein Info for GFF5028 in Sphingobium sp. HT1-2

Annotation: Shikimate 5-dehydrogenase I gamma (EC 1.1.1.25)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08501: Shikimate_dh_N
  • amino acids 14 to 81 (68 residues), 61.3 bits, E=4.4e-21

Best Hits

Swiss-Prot: 54% identical to SHDHL_HAEIN: Shikimate dehydrogenase-like protein HI_0607 (sdhL) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K00014, shikimate dehydrogenase [EC: 1.1.1.25] (inferred from 70% identity to npp:PP1Y_Mpl7746)

Predicted SEED Role

"Shikimate 5-dehydrogenase I gamma (EC 1.1.1.25)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 1.1.1.25)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)
• superpathway of chorismate metabolism (41/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.25

Use Curated BLAST to search for 1.1.1.25

Protein Sequence (267 amino acids)

>GFF5028 Shikimate 5-dehydrogenase I gamma (EC 1.1.1.25) (Sphingobium sp. HT1-2)
MSLSGRPGNAGSRFHNCLYEILGLDYVYKSFSTQDLAAAIGGIRALNVRGCAISMPFKEA
VIPLIDDLESSARAIDSVNTIVNDDGRLTGYNTDYVAVRQLLEKRIEKPVPFLLRGSGGM
AKAVAAALRDAGFANGTIIARNEMAGQAIADQYGFCWQADLPSDSAPLLINVTPLGMEGK
DRDALAFRAEQIAACSTAFDVVAQPVDTPFVRAARAARKSVISGGEVIVLQAVEQFILYT
GVSPGADDIREAARYAHGADVAARIAD