Protein Info for GFF4977 in Sphingobium sp. HT1-2

Annotation: Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.79)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 5 to 455 (451 residues), 457.6 bits, E=2.1e-141

Best Hits

Swiss-Prot: 43% identical to GABD_DEIRA: Succinate-semialdehyde dehydrogenase [NADP(+)] (ssdA) from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 63% identity to zpr:ZPR_3088)

MetaCyc: 42% identical to succinate semialdehyde dehydrogenase (NAD(P)+) Sad (Escherichia coli K-12 substr. MG1655)
Succinate-semialdehyde dehydrogenase. [EC: 1.2.1.24]; Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.24, 1.2.1.20]

Predicted SEED Role

"Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)" (EC 1.2.1.16, EC 1.2.1.24)

MetaCyc Pathways

• 4-aminobutanoate degradation I (1/2 steps found)
• 4-aminobutanoate degradation III (1/2 steps found)
• 4-aminobutanoate degradation IV (1/3 steps found)
• N-methylpyrrolidone degradation (1/3 steps found)
• superpathway of 4-aminobutanoate degradation (1/3 steps found)
• GABA shunt I (1/4 steps found)
• GABA shunt II (1/4 steps found)
• L-lysine degradation X (2/6 steps found)
• L-lysine degradation IV (1/5 steps found)
• L-lysine degradation I (2/7 steps found)
• L-lysine degradation III (1/6 steps found)
• superpathway of L-arginine and L-ornithine degradation (5/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (3/11 steps found)
• superpathway of L-lysine degradation (8/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20 or 1.2.1.24

Protein Sequence (458 amino acids)

>GFF4977 Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.79) (Sphingobium sp. HT1-2)
MSNAEARTINPFTEEVIATYPYMSDDEAMATVQASHEAFLQWRLRSLEERAAVMTAIAQA
LRDAKEEFAQLMTREVGKLIGDSRNEVDLVAAICDYTAKHGPTVLADEERAAEGATAYIT
HAPLGVIYGIQPWNFPAYQAVRYSIASLMAGNGVLLKHAESCTGSGLFLRDLYERAGLPK
GLFGVLVISHEQSDKIIENDLVRGVTLTGSDRAGRAVAAKAGKLVKKTVLELGSNDAYLV
LDDADLDLAIRTCVAGRIYNNGQTCVNAKRFIVTEKNYDAFVEGYVEKFRAIEMGDPTDD
ATKLGPLVSKAQRDQLHSRVEESIAKGARVLAGGKVPDRTGWFYPATVLVDVAPGQPAYD
DELFGPAASIIRAKDDEDAMRIANDSRYGLGGGIFSRNVERARELAAKHFDTGMIFINTF
DVASPDLPFGGVKTSGYGREHGPEGLKEFVNVKSIKIG