Protein Info for GFF4967 in Sphingobium sp. HT1-2

Annotation: Dipeptidyl peptidase IV

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 739 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF00930: DPPIV_N" amino acids 160 to 449 (290 residues), 269.9 bits, see alignment E=8.2e-84 PF02129: Peptidase_S15" amino acids 495 to 645 (151 residues), 48.8 bits, see alignment E=2.5e-16 PF00561: Abhydrolase_1" amino acids 515 to 629 (115 residues), 30.4 bits, see alignment E=9.5e-11 PF00326: Peptidase_S9" amino acids 539 to 732 (194 residues), 184.7 bits, see alignment E=5e-58 PF01738: DLH" amino acids 558 to 711 (154 residues), 38.5 bits, see alignment E=2.9e-13

Best Hits

KEGG orthology group: K01278, dipeptidyl-peptidase 4 [EC: 3.4.14.5] (inferred from 85% identity to sjp:SJA_C1-16910)

Predicted SEED Role

"Dipeptidyl peptidase IV"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.14.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (739 amino acids)

>GFF4967 Dipeptidyl peptidase IV (Sphingobium sp. HT1-2)
MSPYLKAGAALGALLLLPVTTAQAQEKLTLERVFASPDLAGPQPRALKLSPDGKLVTLLK
PRADEKERLDLWAIDTVTGAERMLVDSKKTGSGAELSEAEKMQRERDRSVAGSTGITSYD
WSPDGKTILVPVDGDLYLAALDGKVTRLTDTPDGELNGVVSPKGGFVSFVRGGNLFVKPM
NGAEKQLTQGASDTVSWGVSEFVAQEEMDRRTGYWWSPTDAQIAVARVDESPVGIVTRTA
IGGEGTKVYQQRYPAAGTPNAIVDLFVMNADGSGQVQVDLGADKNVYLARVDWSKDGKTL
YVQRESRDQQRLDLLAVDPTTGRVKIVLTETSKSWINLSNNFTPLRDGSFLWWSEKTGHG
HLYHVRDGKWTALTSGEWEVRDIVGVDEGKSLVYFTGNRETPLEQQLYVASLAKAGPLKA
LTAKGWWNDAVMDGAASRIVVSRQNADQPKQVYLADSSGKQLQWISENALKGDHPYAPYL
ASHARTVFGTVKAADGSTLYTKMLTPPMQPGKRYPVFMIHYGGPGAGRQVTNTWSGALNQ
YLVDRGWIVFSIDNRGTPDRGKAFEDQIHRAMGTVEVDDQLKGVEWLKAQPFVDPERIAT
YGWSYGGYMSLKLAEKAPGTFAAIVSGAPVTKWEFYDTHYTERYLGQPQDKPSAYPGSDA
VDDAVKIKDPLLLIHGMSDDNVVFDNSTALMAKMQGAAVPFELMVYPGQTHRVGGPKISV
HLWTTIENFLRDQGVDPAK