Protein Info for GFF4963 in Sphingobium sp. HT1-2

Annotation: Peptidyl-dipeptidase A precursor (EC 3.4.15.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 607 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF01401: Peptidase_M2" amino acids 31 to 607 (577 residues), 736 bits, see alignment E=1.7e-225

Best Hits

KEGG orthology group: K01283, peptidyl-dipeptidase A [EC: 3.4.15.1] (inferred from 73% identity to swi:Swit_2667)

Predicted SEED Role

"Peptidyl-dipeptidase A precursor (EC 3.4.15.1)" (EC 3.4.15.1)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.15.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (607 amino acids)

>GFF4963 Peptidyl-dipeptidase A precursor (EC 3.4.15.1) (Sphingobium sp. HT1-2)
MKIAISIAALAAALVASPVLAQQAPTPQQPTAAEAEAFLTKAEKALFDQSLISSRAAWIN
ATYITDDTDALASYFGAIDTTMRVDYALEAAKFATAPGLTEETKRRLTLLRTALTLPAPT
TPGASQELNDLATKLQSTYGKGKGTLKGQPINGSDIEEKMGTDRNPDELKEMWVSWHDNV
GAPMRGDYAKLVTIANQGAKELGFADTGAMWRSKYDMPADDFAKLTDKIWAEVKPLYDDL
HCYTRTKLNEKYGDAVQAKTGPIRADLLGNMWAQEWGNIYDIVAPAGAGDLGYDITDLLT
AKNYDPIKMVKTGEGFYSSLGFAPLPQTFWDRSQITKPRDREVICHASAWDLDDKDDIRI
KMCTKVNGDDFVTIHHELGHNYYQRAYNIQKPLYLDGANDGFHEAIGDFIALSITPDYLV
KIGLLDPAKVPGTDKDLGLLLRQAMDKVAFLPFGLLIDKWRWGVFDGSIPESKYESAWTD
LRRQYQGIVPPVSRDETKFDAGAKFHIPGNTPYTRYFLARVLQFQFYEAACRQSGWKGPL
HRCSFYGNKAVGEKLDAMLKMGASKPWPDALQAFTGSREMSGKALVNYFAPLQTWLKTQN
KGKSCGW