Protein Info for GFF4913 in Xanthobacter sp. DMC5

Annotation: Cobalt-zinc-cadmium resistance protein CzcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1043 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 338 to 356 (19 residues), see Phobius details amino acids 362 to 383 (22 residues), see Phobius details amino acids 441 to 462 (22 residues), see Phobius details amino acids 473 to 497 (25 residues), see Phobius details amino acids 531 to 553 (23 residues), see Phobius details amino acids 856 to 874 (19 residues), see Phobius details amino acids 881 to 903 (23 residues), see Phobius details amino acids 909 to 928 (20 residues), see Phobius details amino acids 958 to 978 (21 residues), see Phobius details amino acids 990 to 1016 (27 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1014 (1014 residues), 765.3 bits, see alignment E=5e-234 PF00873: ACR_tran" amino acids 8 to 1012 (1005 residues), 819.7 bits, see alignment E=3.4e-250

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 71% identity to mch:Mchl_0995)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1043 amino acids)

>GFF4913 Cobalt-zinc-cadmium resistance protein CzcA (Xanthobacter sp. DMC5)
MFTVLVTQSLRNRLLVLALALVLVVYGAYAVTRLPVDVLPDLNRPTVTIMTEADGLAPAE
VEQLVTFPLETAMNGLPGLVRLRSVSGVGLSVVYAEFDFGTDIFRNRQQIAERLALVRDR
LPANVAPQMGPISSIMGQVLMFAVTSDTATPMAVREAADFVIRPRLLAIPGIAQVIPMGG
EVRQFRVAPDVSAMRAYGITLDVLEKALSQFGTNSGGGFADQGGREFLIRNIARTLSLDD
LKNLVLPRPAGGSVVLHQIAQVDFAARLKRGEAGYMGEPAVIFSVEKQPEADTLALTGAV
EEAVADLNRTLPDGIRISPPVFRQADFIAASIGNVEKVLLEAMAVVAVVLFLFLLNWRTT
VISLTAIPVSILATAIVFHAFGLSINTMTLGGLAIAIGELVDDAVVDVENIFRRLRENAA
AAAPRPVFDVVVAASREVRSGIVYATLIIVLVFVPLFALPGIEGRLFAPLGQAYIVSILA
SLLTSITLTPVLAFYLLPALSSHADRDGALVRMLKGGYAALLSTAFRHQRLVMAGTALLF
VAALAAAAGLPRAFLPPFNEGSLTISMSFRPGLSLAESHRMGLLAEKLILEVPEVKAVGR
RTGRAELDEHAEGVHASEIEVDLSPSDRSRAEITADIRDRLAVLPASFNLGQPISHRLDH
MLSGVRAEIALKLFGDDIDTLRATAESLRQRLAAIPGLVDLQVERQVRVPEVTVRMDYGR
AALHGLQPAQVTDALARLSNGRVVSTLVDGNRRFDLIVRLPDATRSAEGLARLLIETPSG
WVPLSEVADVKETDGPNQILREGGRRRIVVLANTSGGRDTAAIIADMRRVIAATDLPSGM
STSLEGTFAAQEESMRTIGALGAVSLLLVFAILYSRYRSALFALVIMGSVPLALIGAVAA
LWLAGQPLSVASMIGFVTLTGIAARNGILKISHIINLAIAEGLPFGPALVARGSLERLTP
VLMTATSAGIALLPLMSGAEVPGKEILHPVAVTIFGGLVSATLLDAVLTPVLVLAYGQRP
LERLVAASDEASPLAGTARADAF