Protein Info for GFF4902 in Xanthobacter sp. DMC5

Annotation: Multidrug resistance protein MdtH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 408 transmembrane" amino acids 22 to 37 (16 residues), see Phobius details amino acids 45 to 65 (21 residues), see Phobius details amino acids 95 to 121 (27 residues), see Phobius details amino acids 157 to 177 (21 residues), see Phobius details amino acids 183 to 203 (21 residues), see Phobius details amino acids 230 to 250 (21 residues), see Phobius details amino acids 260 to 283 (24 residues), see Phobius details amino acids 295 to 313 (19 residues), see Phobius details amino acids 319 to 341 (23 residues), see Phobius details amino acids 353 to 376 (24 residues), see Phobius details amino acids 382 to 404 (23 residues), see Phobius details PF07690: MFS_1" amino acids 30 to 368 (339 residues), 151 bits, see alignment E=6.2e-48 amino acids 267 to 402 (136 residues), 46 bits, see alignment E=5.3e-16 PF00083: Sugar_tr" amino acids 77 to 200 (124 residues), 29.6 bits, see alignment E=5.1e-11

Best Hits

KEGG orthology group: None (inferred from 82% identity to xau:Xaut_1271)

Predicted SEED Role

"Permeases of the major facilitator superfamily"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (408 amino acids)

>GFF4902 Multidrug resistance protein MdtH (Xanthobacter sp. DMC5)
MNEVQATGQERRAGAGLDRPAIPRTVWALGLVSMFMDISSEMIHALLPLFLTGTLGASVA
MVGLIEGIGESTAQVVKVFSGYLSDRFGRRKPLILLGYGLGAASKPFFAIAGAPGMVLAA
RFADRVGKGMRGAPRDALVADVTPSEIRGRAYGLRQALDTVGAFVGPLLAIVLMALFADD
MRVVFWIALVPGILAVVCVVAGVEDRAAGVAEGDRPPPVRLKDLKRLGRAFWGVVAVGVV
FTLARFSEAFLVLKAHDEGLPLVLAPLVLVAMNVVYSLGAYPAGAWSDRAPPQRLLFGGL
VLLIAADIVLAFGPGLPGAFLGIILWGGHMALTQGLLAKLVAEHAPAALRGSAFGLFNLA
TGLATLAASLAAGLLWDAGGARATFIAGAVFAFLASALVIALAGGREP