Protein Info for GFF4895 in Sphingobium sp. HT1-2

Annotation: 3-methylmercaptopropionyl-CoA dehydrogenase (DmdC)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 573 PF02771: Acyl-CoA_dh_N" amino acids 78 to 156 (79 residues), 27.3 bits, see alignment E=1e-09 PF02770: Acyl-CoA_dh_M" amino acids 161 to 265 (105 residues), 54.9 bits, see alignment E=2e-18 PF00441: Acyl-CoA_dh_1" amino acids 278 to 429 (152 residues), 109 bits, see alignment E=6.2e-35 PF08028: Acyl-CoA_dh_2" amino acids 296 to 422 (127 residues), 42.6 bits, see alignment E=1.9e-14 PF12806: Acyl-CoA_dh_C" amino acids 442 to 566 (125 residues), 95.7 bits, see alignment E=5.7e-31

Best Hits

KEGG orthology group: None (inferred from 52% identity to dar:Daro_0227)

Predicted SEED Role

"Acyl-CoA dehydrogenase (EC 1.3.8.7)" (EC 1.3.8.7)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.7

Use Curated BLAST to search for 1.3.8.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (573 amino acids)

>GFF4895 3-methylmercaptopropionyl-CoA dehydrogenase (DmdC) (Sphingobium sp. HT1-2)
MSFRVPLVEQLFVLETIANIEGIASLPAFTAATPELIEAVLDESAKLAEQVFAPLNKIGD
IEGSVWRNGEVSLPDGYASAFRQYVAGGWGSLGSDPRWGGQGLPFVLALAVQEQLTAANM
AFALNMMLTLGAIEALQSHASDDLNALYLTKLVSGEWTGTMNLTEPQAGSDVGALRTRAE
PAADGTWRIKGSKIFITWGEHDLAENIVHLVLARTPGSPAGTKGISLFLVPKFLEDGVRN
DLRCVSIEHKLGIHASPTCTMSFGDADGCVGYMVGAENGGMRAMFTMMNHARINVGLQGV
GIAERAYQAALGYARERVQGLRIIDYPDVRRMILTMRATTEAIRALAYFNAAAVDRGHSG
DAQAQMLADLLTPVTKAYATDMGVEVASLGIQVFGGMGFIEETGAAQHFRDARIAPIYEG
TNGIQAMDLVGRKLRQGRWEALFAEIATEIDLAGATPETAALQAPLEAALSALTHATKWM
LDQSDAQDVTAGASPYLRMFGILMGGYLLARQARIACERIAGGTADNLPFLRTKIATASF
FITQILPQAGALLSAATAGAAPLYAISEDQFAA