Protein Info for GFF4880 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Propionate--CoA ligase (EC 6.2.1.17)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02316: propionate--CoA ligase
  • amino acids 18 to 642 (625 residues), 1107.2 bits, E=0
• PF16177: ACAS_N
  • amino acids 18 to 72 (55 residues), 77.6 bits, 7.6e-26
• PF00501: AMP-binding
  • amino acids 74 to 462 (389 residues), 255.6 bits, E=1.1e-79
• PF13193: AMP-binding_C
  • amino acids 526 to 609 (84 residues), 84.4 bits, E=1.3e-27

Best Hits

Swiss-Prot: 65% identical to PRPE_SALTY: Propionate--CoA ligase (prpE) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K01908, propionyl-CoA synthetase [EC: 6.2.1.17] (inferred from 82% identity to pol:Bpro_2633)

MetaCyc: 65% identical to propionate-CoA ligase (Salmonella enterica enterica serovar Typhimurium)
Propionate--CoA ligase. [EC: 6.2.1.17]

Predicted SEED Role

"Propionate--CoA ligase (EC 6.2.1.17)" in subsystem Methylcitrate cycle or Propionate-CoA to Succinate Module (EC 6.2.1.17)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis II (plants) (9/10 steps found)
• acrylate degradation II (3/3 steps found)
• β-alanine biosynthesis II (5/6 steps found)
• L-isoleucine biosynthesis IV (4/6 steps found)
• 2-methylcitrate cycle I (3/5 steps found)
• 2-methylcitrate cycle II (3/6 steps found)

KEGG Metabolic Maps

• Propanoate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.17

Protein Sequence (644 amino acids)

>GFF4880 Propionate--CoA ligase (EC 6.2.1.17) (Hydrogenophaga sp. GW460-11-11-14-LB1)
VHDFWVHLLQETFMNQGYAEFYRRSIEDRDAFWTEQAALVDWHKPFDRVCNHDNPPFAHW
FEGGLTNLCHNAVDRHLKDRADHNALIYVSTETDTERTYSFRELHAEVQRMAAVLLGQGV
KKGDRVLIYMPMIPEATFAMLACARIGAIHSVVFGGFASHSLANRIDDASPVAIVSADAG
SRGGKVVEYKPLLDEAIRLSSHKPASVVLVNRGLAPMSLVPGRDHDYAALREQHLNAQVP
CEWMESTAISYTIYTSGTTGKPKGVQRDTGGYLVALAASMKHIFMGEAGETYFSTSDIGW
VVGHSYIVYGPLIAGMATILYEGLPIRPDGGIWWRLVEKYKVTVMFSAPTAVRVLKKQDP
AYLKQYDLSSLKALFLAGEPLDEPTARWISDSLGVPIIDNYWQTESGWPILTIANGVEKK
PSKFGSPGVPMYGYRVKLLHESTGEELTGADEKGVVVIEGPTPPGFMQTVWRDDARFINT
YWKSIPGKLVYSTFDWGIRDQDGYFYILGRTDDVINVAGHRLGTREIEESISSHANVAEV
AVVGVADQLKGQVAMAFVVAKDTSGLVDDASRLKLEGEIMKRVDEQLGAVARPARVRFVT
VLPKTRSGKLLRRAIQAVCEGRDPGDLTTMDDPAALQQIKDLLA