Protein Info for GFF488 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: RND multidrug efflux transporter; Acriflavin resistance protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1043 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 335 to 354 (20 residues), see Phobius details amino acids 361 to 382 (22 residues), see Phobius details amino acids 388 to 408 (21 residues), see Phobius details amino acids 446 to 468 (23 residues), see Phobius details amino acids 478 to 502 (25 residues), see Phobius details amino acids 543 to 563 (21 residues), see Phobius details amino acids 871 to 889 (19 residues), see Phobius details amino acids 896 to 915 (20 residues), see Phobius details amino acids 922 to 948 (27 residues), see Phobius details amino acids 970 to 990 (21 residues), see Phobius details amino acids 1001 to 1026 (26 residues), see Phobius details PF00873: ACR_tran" amino acids 5 to 1026 (1022 residues), 967.6 bits, see alignment E=7.2e-295 PF02355: SecD_SecF_C" amino acids 333 to 499 (167 residues), 21 bits, see alignment E=2e-08

Best Hits

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1043 amino acids)

>GFF488 RND multidrug efflux transporter; Acriflavin resistance protein (Hydrogenophaga sp. GW460-11-11-14-LB1)
MNALARFFIRRPIGSVMLAVGIVLVGLLAWRLLPVSPLPRVDFPVIQVRASLPGASPESM
ASTVAAPLERALGSIAGVASIRSSSNQGSTSVTLQFNLDRDIDEAAREVQAAINASRGQL
PSGMTGNPSYVKVNPSQAPIMALALSSPRLPSSALYDNASTVLAQKLAQIVGVGEVTVDG
SSLPAVRVQARPEALSHRGMSLDDVRQAIAQANAWRPLGQTEQGGQRWQIALPTPLRTAA
DFSQLVVRNEGGALVRLADVAEVTDSVENRYTAGYHNDRPAVVLLVSRRAGANIVQTIDA
IHAQLPQLRALLPADTELRVVMDRSPGIRATLREAQFTLVLSCVLVMAVVWAFLGSVRTA
LIPALALPVSLIGAFAVMWWQGFSLNNLSLMALIVAAGLVVDDAIVVLENIQRHIERARA
AQAANGQREVGRRTVWRAAFTGAGEVGFTLLAMNLALIVVFISILFMGGVVERLFREFSI
TLVAAMLISLAVSVTLTPALCAHGLPAGPPKPPGPLARGIAGLLADVQAGYARSLGFALR
HRVLTLLLLAGTVALNVWLYVAIPKGMLPQQDTGQLGGFVRGDDGFSFQGMQPKVEAFRR
LLVADPAVADVTGVSGGRTGTSNSWFRIRLKPLAERGEPASTVVARLRANAPKIAGGVLF
VNVDQDIRLSSGGGDNEYLFVMRSDSLQDLRGWTKPVGEALRALPELTDVDFGAGEDAQQ
VVLNVDREAARRLGVRMDTVTTALNNAFSQRQVATLYDPLNQYRVVMEADPRGNSEPAAL
DQVQLLNDAGERVPLSAIASWRYGLTRDRVQHDAQFASAGISYALAPGVSLQQAQQAIDR
AVNGLLLPTSISTGERAGDPNSLQATLKRQPWLILAVLLTVYLVLGMLYESTLHPLTILS
TLPSAGVGALLALRISDTEFSLIALLGLFLLIGVVMKNAILMIDFALAAQRTRGLAPQAA
IHEAALRRLRPILMTNLAALLGAVPLVLGLGEGSELRRPLGIAIIGGLAVSQLLTLYTTP
VVYLALERLRRRVQGPSPVAQTA