Protein Info for GFF4868 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01479: S4
  • amino acids 42 to 85 (44 residues), 37.1 bits, 2e-13
• PF00849: PseudoU_synth_2
  • amino acids 103 to 236 (134 residues), 70.4 bits, E=2e-23
• TIGR00093: pseudouridine synthase
  • amino acids 107 to 267 (161 residues), 173.1 bits, E=1.9e-55

Predicted SEED Role

"Ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70)" in subsystem Two cell division clusters relating to chromosome partitioning (EC 4.2.1.70)

MetaCyc Pathways

• pseudouridine degradation (1/2 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.70

Use Curated BLAST to search for 4.2.1.70

Protein Sequence (403 amino acids)

>GFF4868 Ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70) (Hydrogenophaga sp. GW460-11-11-14-LB1)
VAPPEALRFDDVVSGAFDAEQEQDQSLPTKRVLAPQAESPKLHKVLAQAGMGSRLEMEQL
ILEGRISVNGEPAHIGQRIQFGDVIKVNGKPVRVRMTPPPPRVLAYHKPAGEVVSHDDPQ
NRPTVFRRLPKLMQGKWQSVGRLDLNTEGLLLLTNSGELANRLMHPRFGLQREYAVRVLG
ALSNEEKQRLLDGVKLDDGVAQFASIEDGGGEGANCWYRVTIGEGRNREVRRMFEAVGHA
VSRLIRIRYGAVMLPRGLKRGVWLELDDRDIARLTAAAGLVEADEPRGPRPGGRHPAQRG
KQGAKGGRTQGKPPGSRPEGPGFGDRRTNSGYGMGGAPGGAKPRGAKGPGKGQGGAGSQP
DPMKTSFGYIGQDALQRRREQDAGRGGPPGGGRRRGGGRSGGR