Protein Info for GFF4837 in Sphingobium sp. HT1-2

Annotation: Excinuclease ABC subunit A paralog of unknown function

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 886 PF17755: UvrA_DNA-bind" amino acids 174 to 287 (114 residues), 47.2 bits, see alignment E=6.5e-16

Best Hits

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 74% identity to bxe:Bxe_A0918)

Predicted SEED Role

"Excinuclease ABC subunit A paralog of unknown function" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (886 amino acids)

>GFF4837 Excinuclease ABC subunit A paralog of unknown function (Sphingobium sp. HT1-2)
LKSKDIHATTPATDHGHTGPPACVQIRGARQNNLKNVDVDVPRNAFVVFTGISGSGKSSL
AFGTLYAEAQRRYLESVAPYARRLIDQAGVPEVDAIDGLPPAVALQQQRGSANARSSVGS
VTTLSSLVRMLYSRVGEYPRHQPMLYAEDFSPNTVAGACPTCHGIGRVYDATEETMVPDD
TLTIRERAVAAWPAAWHGQNLRDILVSLGYNVDTPWRDLPKKDRDWILFTDEAPTVPVYA
GLTPEQTRVALKRRMEPSYQGTFTGARRYVLETFANTKSALMKKRVSQYIIGRDCPTCDG
KRLKREALSVKFAGLDIAEFGDLTVLKLRDLLTPVAHGEYGGAAAVPKSHVLGKAARDAA
VERRVAAGGSAHKSAPDVRRTPNLSDEKRIAAQRLASELIERLEPLIDLGLGYISLDRST
PTLSSGELQRLRLATQLSSQLFGVVYVLDEPSAGLHPADGEALLTILERLKAAGNSLFVV
EHDLDVIRRAEWLVDVGPGAGEKGGEVLYSGPIEGLANVETSITRRYLFAEPLRSEHTPR
DAKAWLRLEGIRRNNLHGLDVEFPIGCFTAVTGVSGSGKSSLVSQALPELVTEHLGGSPV
AEEEDIDPLLDVAQNDTEGRIVAGMEHVRRLVRVDQKPIGRTPRSNLSTYSGMFDHVRRI
FADTPLARRRHYSPGRFSFNVAQGRCPVCEGEGYVMVELLFLPSVFAPCSTCHGSRYNPQ
TLEVEWNGRNIAQVLELTVDDACDFFAGEASVMRSLDVLREIGLGYLRLGQPATELSGGE
AQRIKLATELQRAQRGNTIYILDEPTSGLHPSDGDRLMRHLRGLVEAGNTVVVVEHDMRA
ITQADWIIDLGPGAGEDGGRIVASGVPGVVAEAEGSLTARYLKAAL