Protein Info for GFF4783 in Sphingobium sp. HT1-2

Annotation: 5-oxoprolinase (EC 3.5.2.9), HyuA-like domain / 5-oxoprolinase (EC 3.5.2.9), HyuB-like domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1193 PF05378: Hydant_A_N" amino acids 5 to 179 (175 residues), 164 bits, see alignment E=4.7e-52 PF01968: Hydantoinase_A" amino acids 199 to 486 (288 residues), 338.3 bits, see alignment E=5.9e-105 PF02538: Hydantoinase_B" amino acids 675 to 1192 (518 residues), 638.9 bits, see alignment E=8.4e-196

Best Hits

Predicted SEED Role

"5-oxoprolinase (EC 3.5.2.9)" in subsystem Glutathione: Biosynthesis and gamma-glutamyl cycle (EC 3.5.2.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1193 amino acids)

>GFF4783 5-oxoprolinase (EC 3.5.2.9), HyuA-like domain / 5-oxoprolinase (EC 3.5.2.9), HyuB-like domain (Sphingobium sp. HT1-2)
MQWQFWIDRGGTFTDVVARDPQGALHTVKLLSSDPERYADAAVEAIRRLTGAGDGPIPPC
TLRIGTTIATNALLERKGEPVLLAITKGFRDAIRIGYQDRPDLFARRIDLPPPLHADVVE
MDERLMQDGTILTPLDEVAAQAALQRGYDDGLRAVAIVLMHGYRYPAHEQALARIARQIG
FTQISVSHEVAPLIKLVGRGDTVLADAYLSPVLRAYVDGLGEALGEDADMLFMQSNGGLT
RGDLFRGKDAVLSGPAGGIVGLARTAEQAGFGEVIGFDMGGTSTDVSHYAGSYERDNEAR
VAGVRLRAPMMRIHTIAAGGGSICSVVDGRFRVGPESAGAVPGPACYRRGGPLTITDCNV
MLGKVQPDFFPSLFGPRGDQPLDRDAVEARFADICAQVEAQTGRVMTAQEAAQGFIAVAV
ASMANAIKRISVARGHDVARYTLASFGGAGGQHACLVADALGMDRVMIHPLGGVLSAYGM
GLADRRAVRERTLALPLDDAGADALTAAIAELAAQARADLPEAERSETVLRLRYDGTDSL
FDVMLGDRAAMLADFEAQYQARFGYGGTGTILVDMVRVEAIAPTAEDMGKVATIATQAAA
PLAQVMLAGVPAPVFDRAGLTLDSIVDGPALISDPVSTTVVEPGWRARLDAIGNLVLTRH
APRPAPAADDGTAVDPIRLEVMGGLFMAIAEEMGAALQHSASSVNIRERLDFSCALFDAT
GNLVANAPHMPVHLGSMGESIRAVMRRRGIGADGRAIDGRGMLPGDVYALNAPYDGGTHL
PDVTVVMPVFVDETAHAPAFYVAARGHHADIGGISPGSMPPDSRSIEEEGIVLDNVLVVD
QGRFLEGDLRTLLGVGRWPSRNVDQNIADLSAQIAACAKGAAELQRISGDYGADVVAAYM
GHVQDQAEAAVRRLIDRLSDGHYRYAMDNGAEVVVNVTIDRAARGATVDFTGTSDQLPGN
FNAPLSVARAALLYVVRTLVDEAVPMNDGCLKPMTLVVPEGSLLRPLYPAAVVAGNVETS
QVVTDALFGALGVMAGAQGTMNNFTFGNARHQYYETISGGSGAGPDFDGADVVQTHMTNS
RLTDPEILESRFPVLLEEFSIRPGSGGAGAHHGGNGGLRRIRFLEDMTAGILANRRSVPP
FGLEGGAPGGLGRNWVERGDGRIEMLGATGSADMAPGDVFVIETPGGGGFGKG