Protein Info for GFF4782 in Variovorax sp. SCN45

Annotation: Pyridoxal-5'-phosphate-dependent enzyme beta superfamily (fold type II)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00291: PALP
  • amino acids 36 to 323 (288 residues), 185.6 bits, E=6.9e-59

Best Hits

KEGG orthology group: K01738, cysteine synthase A [EC: 2.5.1.47] (inferred from 93% identity to vap:Vapar_3479)

Predicted SEED Role

"Cysteine synthase B (EC 2.5.1.47)" in subsystem Cysteine Biosynthesis (EC 2.5.1.47)

MetaCyc Pathways

• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• L-cysteine biosynthesis I (2/2 steps found)
• seleno-amino acid biosynthesis (plants) (3/5 steps found)
• superpathway of seleno-compound metabolism (8/19 steps found)

KEGG Metabolic Maps

• Cysteine metabolism
• Selenoamino acid metabolism
• Sulfur metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.47

Use Curated BLAST to search for 2.5.1.47

Protein Sequence (358 amino acids)

>GFF4782 Pyridoxal-5'-phosphate-dependent enzyme beta superfamily (fold type II) (Variovorax sp. SCN45)
MQQILSSSSCNAWLDSAIRRIEADYQRSADTHLIPLPLPALAAQGIDLYMKDESTHPTGS
LKHRLARSLFLYALCNGWVREGTTIVEASSGSTAVSEAYFARLLGLPFIAVMPRATSPEK
IAQIAFYGASCHFVDHAAQVYEEARSLAERTGGHYMDQFTYAERATDWRGNNNIAESMFQ
QMARERHPVPTWIVVGAGTGGTSATIGRYLRYRCHDTQVCVADPEGSVFSAYHRTGDATL
TAPGSRIEGIGRPRVEPSFIRTLVDRMIEVPNLDSVAAMHALSALLGRKVGPSTGTNFVG
MLAVAQEMRAAGQQGSILSLLCDAGERYLPSYHDAAWVRNAFGDIGPAQRRIDALVAA