Protein Info for GFF4782 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868
Annotation: D-beta-hydroxybutyrate dehydrogenase (EC 1.1.1.30)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 82% identical to LTND_ECOL6: L-threonate dehydrogenase (ltnD) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
KEGG orthology group: K08319, putative dehydrogenase [EC: 1.1.-.-] (inferred from 99% identity to see:SNSL254_A3123)MetaCyc: 71% identical to L-threonate 2-dehydrogenase (Haemophilus influenzae Rd KW20)
RXN-18590 [EC: 1.1.1.411]
Predicted SEED Role
"D-beta-hydroxybutyrate dehydrogenase (EC 1.1.1.30)" in subsystem Polyhydroxybutyrate metabolism (EC 1.1.1.30)
MetaCyc Pathways
- L-threonate degradation (3/4 steps found)
- ketolysis (2/3 steps found)
- ketogenesis (3/5 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- Benzoate degradation via CoA ligation
- Bisphenol A degradation
- Butanoate metabolism
- Ethylbenzene degradation
- Limonene and pinene degradation
- Naphthalene and anthracene degradation
- Retinol metabolism
- Synthesis and degradation of ketone bodies
- gamma-Hexachlorocyclohexane degradation
Isozymes
Compare fitness of predicted isozymes for: 1.1.-.-
Use Curated BLAST to search for 1.1.-.- or 1.1.1.30 or 1.1.1.411
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (307 amino acids)
>GFF4782 D-beta-hydroxybutyrate dehydrogenase (EC 1.1.1.30) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868) MTTGTDFHVGIVGLGSMGMGAARSCLRAGLSTWGADLNPQACANLLAEGACGAAASAREF AGVVDALVILVVNAAQVRQVLFGEDGVAHLMKPGSAVMVSSTISSADAQEIAAALTALNL NMLDAPVSGGAVKAAQGEMTVMASGSEAAFTRLKPVLDAVASNVYRISDTPGAGSTVKII HQLLAGVHIAAAAEAMALAARAGIPLDVMYDVVTHAAGNSWMFENRMQHVVDGDYTPRSA VDIFVKDLGLVADTAKALRFPLPLASTALNMFTSASNAGYGKEDDSAVIKIFSGITLPGV TPEEPSC