Protein Info for PS417_24445 in Pseudomonas simiae WCS417

Annotation: 4-hydroxyphenylpyruvate dioxygenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01261: AP_endonuc_2
  • amino acids 18 to 261 (244 residues), 152.6 bits, E=3.1e-48
• PF14696: Glyoxalase_5
  • amino acids 293 to 425 (133 residues), 118.8 bits, E=4.3e-38
• PF00903: Glyoxalase
  • amino acids 438 to 560 (123 residues), 42.2 bits, E=2.1e-14

Best Hits

KEGG orthology group: K00457, 4-hydroxyphenylpyruvate dioxygenase [EC: 1.13.11.27] (inferred from 98% identity to pfs:PFLU5367)

Predicted SEED Role

"4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27)" in subsystem Aromatic amino acid degradation or Homogentisate pathway of aromatic compound degradation or Plastoquinone Biosynthesis or Tocopherol Biosynthesis (EC 1.13.11.27)

MetaCyc Pathways

• L-tyrosine degradation I (5/5 steps found)
• plastoquinol-9 biosynthesis I (1/3 steps found)
• superpathway of plastoquinol biosynthesis (2/5 steps found)
• L-phenylalanine degradation IV (mammalian, via side chain) (3/9 steps found)
• vitamin E biosynthesis (tocopherols) (1/7 steps found)

KEGG Metabolic Maps

• Phenylalanine metabolism
• Tyrosine metabolism
• Ubiquinone and menaquinone biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.13.11.27

Use Curated BLAST to search for 1.13.11.27

Sequence Analysis Tools

See A0A1N7UCF2 at UniProt or InterPro

Protein Sequence (633 amino acids)

>PS417_24445 4-hydroxyphenylpyruvate dioxygenase (Pseudomonas simiae WCS417)
MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLYYDGSPREVRQMCADLGIAITLF
QPFRDFEGCRRDRLARNLERAERKFDLMQELGTDLVLVCSNASADCVGDERILLDDLSLL
AEHAGRRGLRIGYEALAWGKHVNTWQQVWNLVRQVDHPNLGVLLDSFHTLSLKGDPSAIA
EIPGDKIFFVQMADAPILAMDVLEWSRHFRCFPGQGEFDLAGFLAPIIKSGYTGPLSLEI
FNDGFRAAPTRANAADGLRSLLYLEEKTRERLQQEAPAQPLDILFDTPAASEYDGIEFLE
FAVDESLGAKLTYWLERLGFVKAGQHRSKSVSLLRQGDINLILNCEPYSFAHNFFEAHGP
SLCATAIRVKDSAKALERAMAYKGQPYRGLVGPNELELAAVRAPDGSLIYLVDPSEGGLY
DTDFNLQPAASSSGGLLRIDHMAMALPADSLDSWVLFYKSLLDFEADDEVVLPDPYGLVK
SRALRSRCSSIRLPLNISENRNTAISHALSSYRGSGVHHIAFDCADIFAEVRRAKEAGVP
LLDIPLNYYDDLAARFDFDDEFLSELAYYNVLYDRDAQGGELFHVYTEPFEGRFFFEIIQ
RKNGYAGYGAANVAVRLAAMAKSRSGAVRQARL