Protein Info for GFF4764 in Sphingobium sp. HT1-2

Annotation: Threonine synthase (EC 4.2.3.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF14821: Thr_synth_N
  • amino acids 2 to 80 (79 residues), 94.8 bits, E=4.2e-31
• TIGR00260: threonine synthase
  • amino acids 69 to 426 (358 residues), 256.1 bits, E=2.6e-80
• PF00291: PALP
  • amino acids 87 to 333 (247 residues), 65.1 bits, E=1.1e-21
• PF24857: THR4_C
  • amino acids 387 to 424 (38 residues), 31.7 bits, 2e-11

Best Hits

KEGG orthology group: K01733, threonine synthase [EC: 4.2.3.1] (inferred from 91% identity to sjp:SJA_C1-06770)

Predicted SEED Role

"Threonine synthase (EC 4.2.3.1)" in subsystem Threonine and Homoserine Biosynthesis (EC 4.2.3.1)

MetaCyc Pathways

• aspartate superpathway (25/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
• superpathway of L-isoleucine biosynthesis I (13/13 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• superpathway of L-threonine biosynthesis (6/6 steps found)
• L-threonine biosynthesis (2/2 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Vitamin B6 metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.2.3.1

Use Curated BLAST to search for 4.2.3.1

Protein Sequence (466 amino acids)

>GFF4764 Threonine synthase (EC 4.2.3.1) (Sphingobium sp. HT1-2)
MQYVSTRGSAPALGFEDVTLAGLASDGGLYVPESWPQFSAADIRAFAGLSYVETAVRVMA
PFVAGSLSEEELRELCTAAYGRFSHDAVTPLVQLDNRHWMLELFHGPTLAFKDVALQLLG
QLFERFLSRRDDHLTIVGATSGDTGSAAIDAVAGREKVDIFMLHPEGRVSDVQRRQMTTV
LAPNVYNIAIDGSFDDAQALVKRMFNDADFKARFNLSAVNSINWARLMAQVVYYFYAAVR
LGAPDRPIAFSVPTGNFGDVFAGYVASKMGLPVAKLVVATNVNDILHRALSEGDYSQGQV
VPTATPSMDIQVSSNFERLLFDAGGRDGVALAQQMQGFEASKAMRLTNAQREGAANLFTS
ARIDADGMTMAMRWAFDAAGQVIDPHSAIGLAAAREADIDPSIPVVTLATAHAAKFRDAV
ERATGTRPPLPARVGDLFAREESYAKLPGTFEAVTAYVAERATPRG