Protein Info for GFF4752 in Variovorax sp. SCN45

Annotation: NADH-ubiquinone oxidoreductase chain C (EC 1.6.5.3)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00329: Complex1_30kDa
  • amino acids 35 to 164 (130 residues), 144.5 bits, E=1.2e-46
• TIGR01961: NADH (or F420H2) dehydrogenase, subunit C
  • amino acids 36 to 162 (127 residues), 129.2 bits, E=5.8e-42

Best Hits

Swiss-Prot: 74% identical to NUOC_POLSJ: NADH-quinone oxidoreductase subunit C (nuoC) from Polaromonas sp. (strain JS666 / ATCC BAA-500)

KEGG orthology group: K00332, NADH dehydrogenase I subunit C [EC: 1.6.5.3] (inferred from 94% identity to vap:Vapar_3508)

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain C (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3

Protein Sequence (203 amino acids)

>GFF4752 NADH-ubiquinone oxidoreductase chain C (EC 1.6.5.3) (Variovorax sp. SCN45)
MTDFAISPEVLRATIAETLGDKAKSVTIALGEVTVVVDSTDYIDAALLLRDAPGCRFEQL
IDLCGMDYSDYREGEWQGDRYGVVTHLLSVSLNQRVRLKVFASSEDLPVVDSLQPVWNAA
TWFEREAFDLYGIVFEGHDDLRRILTDYGFIGHPFRKDFPVSGHVEMRYDEEQKRVVYQP
VSIEPREITPRVIREDNYGGGLH