Protein Info for GFF4750 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Type III secretion negative modulator of injection (YopK,YopQ,controls size of translocator pore)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 409 PF09599: IpaC_SipC" amino acids 47 to 397 (351 residues), 502.5 bits, see alignment E=3.9e-155 TIGR02101: type III secretion target, IpaC/SipC family" amino acids 69 to 404 (336 residues), 425.9 bits, see alignment E=6.5e-132

Best Hits

Swiss-Prot: 100% identical to SIPC_SALTY: Cell invasion protein SipC (sipC) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K13286, invasin C (inferred from 100% identity to stt:t2786)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (409 amino acids)

>GFF4750 Type III secretion negative modulator of injection (YopK,YopQ,controls size of translocator pore) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAP
GVLTQTPGTITSFLKASIQNTDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDIS
GMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAKTTASSMMREGMNALSGSISQ
SALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGV
DSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKDSNKQISPEHQAILSKRLESV
ESDIRLEQNTMDMTRIDARKMQMTGDLIMKNSVTVGGIAGASGQYAATQERSEQQISQVN
NRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASALAAIAGNIRA