Protein Info for GFF4746 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2148 PF00109: ketoacyl-synt" amino acids 25 to 275 (251 residues), 328.8 bits, see alignment E=2.1e-101 PF02801: Ketoacyl-synt_C" amino acids 283 to 400 (118 residues), 149.7 bits, see alignment 3.2e-47 PF16197: KAsynt_C_assoc" amino acids 405 to 516 (112 residues), 41.6 bits, see alignment 1.3e-13 PF22621: CurL-like_PKS_C" amino acids 469 to 530 (62 residues), 60.7 bits, see alignment (E = 9.4e-20) PF22336: RhiE-like_linker" amino acids 471 to 535 (65 residues), 32.8 bits, see alignment (E = 4.5e-11) PF00698: Acyl_transf_1" amino acids 555 to 872 (318 residues), 217 bits, see alignment E=4.1e-67 PF21089: PKS_DH_N" amino acids 918 to 1007 (90 residues), 48.2 bits, see alignment (E = 7.5e-16) PF14765: PS-DH" amino acids 1050 to 1202 (153 residues), 111 bits, see alignment 4e-35 PF22953: SpnB_Rossmann" amino acids 1280 to 1429 (150 residues), 56.8 bits, see alignment 3.4e-18 PF08240: ADH_N" amino acids 1469 to 1547 (79 residues), 47.2 bits, see alignment (E = 2e-15) PF00107: ADH_zinc_N" amino acids 1590 to 1678 (89 residues), 66.4 bits, see alignment (E = 2.1e-21) PF13602: ADH_zinc_N_2" amino acids 1622 to 1758 (137 residues), 65.5 bits, see alignment 8e-21 PF08659: KR" amino acids 1776 to 1955 (180 residues), 187 bits, see alignment E=2.6e-58 PF00106: adh_short" amino acids 1778 to 1939 (162 residues), 45.3 bits, see alignment 6.2e-15 PF13561: adh_short_C2" amino acids 1785 to 1937 (153 residues), 36.8 bits, see alignment 2.9e-12 PF00550: PP-binding" amino acids 2059 to 2125 (67 residues), 51.5 bits, see alignment (E = 8.1e-17)

Best Hits

Predicted SEED Role

"Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 2.3.1.39)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.39

Use Curated BLAST to search for 2.3.1.39

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (2148 amino acids)

>GFF4746 Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MLQNALGAIERLQSRLDAVESAKHEPIAIVGMACRVPGGAEDADSFWKLLTEGKDVVGEV
PADRWEVDAYYDPDPSKQGKARTKAGGFLKDIDQFEPSFFGMSPREAAGVDPQQRLLLEV
AWEAMEHAAIPTDQLDGSLTGVFVGITSMDYSNRIDVADPARSDIYLATGTALNAAAGRV
SFTFGFRGPCMAIDTACSSSLVAIHTACQSLRNGESNLVLAGGVNAILSPDPFVLISKWG
MLSPDGRCKTFDASANGFVRGEGCGLIVLERLSDAVANGRRILGVIPGSAINQDGRSSGL
TVPNGLAQQEVVRQALASARLQPTDVSYVEAHGTGTSLGDPIEVEALAAVYGEGRAMQQP
FEIGSVKSNIGHLEAASGVASVIKLVMALRHQQLPASLHVKQLTPSIPWETLPVRVSTAL
HDWKPVGDVRRVAGASAFGFSGMNAHVLVAEPPAAPALAAAPARPLYAMPLSAKNDAALQ
ALAQRYANHLEQRPADALADVCATAAIGRSHHLLRTVLVAADRAGMQAQLRELASTGQSA
VQGSVSASGRNRVAFLFTGQGAQYVGMGRELYDAEPVFRATIDRCAAVLDPLLGKPLREV
MFEETGGSLDQTGFTQPALFAIEVALAATWRSWGIEPTVVIGHSVGEFAAAVVAGVFSLE
DGARLIAARGRLMQALPAGGAMVSVQGDAALVQREIAPHADKVSIAAFNAPGNLVIAGAG
AEVTAIAARLAEQGLRTQALSVSHAFHSPLMDPMVAEFRQLAAGVTHSAPTLTWISNLDG
APMDWAKWGTRMADYWASHVRAPVAFESGARALAATQCDVHLEVGPNPTLIGLGMQCVPE
GTAATDWLPSLKRSKGGWEQMLDSVARLYVRGAKLNWTAVQGPGVRHSLELPLYPFQRQA
YLIPFASRTRRVAGDSVHDLLGERLNVAGVAAQFERTVDATSPAWVVDHVIASEAVMPLT
AYLEAALAGARQADPTVTGLTAVEIGEPMPLLDGEQRLMQVSVDKALGGVPSRVRVFSRD
AKRPEAEWTQHATAEPLRGPAQGVPVSPVAEAAKRLTNEVEVTPFYEKVRKLGVDFGAGF
RGMRRVWCGEGEAIGEIVLTDAVQADAGKYLMHPALLDACFHTSAVAMDTLPSANDGRFY
LPIGVDRYLWNASPTGTLRSHARVRPAPPHSDMLVLDVHIETPDGQPVALLEGLRCRRAS
RELFRQRVDAQVADWLYELQWKPEALVAEPATAEGTWLVFDEGQGRGQRLADEIAQRGGQ
AFRVLPSGSAAGPGATVIDETQAGEYARLVAKAAESGALRGVVSLWPLRVPALRDDDLPS
AVQRFGVDAALLTLQALAQADLPSAPRLWIATAGSQSVDGTEELRITQAPVAGLARVAAS
EHPELRVTLVDLDPQATPSDARLLLDEMLAGSEETQVALRKGVRHAARLARQPRSSAPHI
DDAPIRLNITERGTLENLNLGAMERRAPGRGEVEIRVRASGLNFRDVLSALGMYPGEIRH
LGSDAAGEVVAVGEGVTQFKVGDRVVAMLEGAFSSHAVARWEFVAPLPAGVSFEQGAAIP
TAYLTADITLNLLGKMSQGDRVLIHSGAGGVGMAAIALARRAGAEIFATAGSPEKREELR
RLGVHHPLDSRSDSFADEIARITEGKGVRLVLNSLAGQLLDRSFECLSDGGVFLEIGKRG
LWTHERVAELNRGIEYHIVDCNDNARDTPEIVGQIFTRVLQEIESGVLPWLPCTTFPFEN
APDAFRYMAQAKHIGRVVFRHRVDPRKLPQAVQDDATYLVTGGLKGLGLLAGQWLAGEGA
RHLLLAGRSEPDATAREAIAAMEAEGVSVKTVSADVATADGIARLMAALKDMPALGGVVH
GAAVLDDGVLLKQTPERFATVMGPKADGAWRLSVALERAGHRPDFVVFYSSLSAVFGSAG
QGNYVAANAFLDALARQRRDADRSALSVNWGAWSEVGMAVRAGTVSRAGAQGLASLSPAE
GMQALSVLLRDNATRSSVAPIDWALLGQQMPAGQAPRLLADLLAAAQNRGGSQAQGSAAR
VDYASLPAKERREQLVTLVRRELATVLGLAGSPQSIPVDQTFTALGLDSLTSVELRNRLQ
QALGRSVAATAAFEWPSVGEMATHLNSLYGDEDASDAADSDSREELTL