Protein Info for PS417_24005 in Pseudomonas simiae WCS417

Annotation: phosphoglucosamine mutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02878: PGM_PMM_I
  • amino acids 4 to 134 (131 residues), 153.2 bits, E=7.1e-49
• TIGR01455: phosphoglucosamine mutase
  • amino acids 6 to 441 (436 residues), 632 bits, E=2.3e-194
• PF02879: PGM_PMM_II
  • amino acids 156 to 253 (98 residues), 73.1 bits, E=4.8e-24
• PF02880: PGM_PMM_III
  • amino acids 257 to 364 (108 residues), 111.9 bits, E=3.9e-36
• PF00408: PGM_PMM_IV
  • amino acids 372 to 440 (69 residues), 52.6 bits, E=7.7e-18

Best Hits

Swiss-Prot: 96% identical to GLMM_PSEFS: Phosphoglucosamine mutase (glmM) from Pseudomonas fluorescens (strain SBW25)

KEGG orthology group: K03431, phosphoglucosamine mutase [EC: 5.4.2.10] (inferred from 96% identity to pfs:PFLU5258)

MetaCyc: 61% identical to phosphoglucosamine mutase (Escherichia coli K-12 substr. MG1655)
Phosphoglucosamine mutase. [EC: 5.4.2.10]

Predicted SEED Role

"Phosphoglucosamine mutase (EC 5.4.2.10)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 5.4.2.10)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
• peptidoglycan recycling I (11/14 steps found)
• glycogen degradation II (5/6 steps found)
• UDP-α-D-glucose biosynthesis (2/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• glucose and glucose-1-phosphate degradation (4/5 steps found)
• sucrose degradation II (sucrose synthase) (4/5 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• glycogen degradation I (6/8 steps found)
• sucrose biosynthesis II (6/8 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (3/4 steps found)
• starch degradation V (3/4 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• colanic acid building blocks biosynthesis (8/11 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (3/5 steps found)
• D-galactose degradation I (Leloir pathway) (3/5 steps found)
• starch degradation III (2/4 steps found)
• chitin biosynthesis (5/9 steps found)
• glucosylglycerol biosynthesis (2/5 steps found)
• starch biosynthesis (5/10 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (3/8 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (9/24 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (5/19 steps found)
• streptomycin biosynthesis (3/18 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.2.10

Sequence Analysis Tools

See A0A1N7U1I1 at UniProt or InterPro

Protein Sequence (445 amino acids)

>PS417_24005 phosphoglucosamine mutase (Pseudomonas simiae WCS417)
MTKKYFGTDGIRGRVGEFPITPDFMLKLGWAAGMAFRSMGACRILVGKDTRISGYMFESA
LEAGLSAAGADVLLLGPMPTPAIAYLTRTFHAEAGIVISASHNPHDDNGIKFFSGQGTKL
PDEIELMIEELLDAPMTVVESSKLGKVSRINDASGRYIEFCKSSVPSSTSFAGLKLVVDC
AHGATYKVAPSVFKELGAQVTVLSAQPDGLNINENCGSTHMEQLQAAVLAEHADLGIAFD
GDGDRVLMVDHTGAIVDGDELLFIIARDLHERDRLQGGVVGTLMSNLGLELALSDLGIPF
VRANVGDRYVIAELLERNWLIGGENSGHVVCFQHTTTGDAIIAALQVLMALRARGESLAQ
SRQALRKCPQVLLNVRFSGGENPIEHPAVKEACERVTLAMAGRGRVLLRKSGTEPLVRVM
VEGDDETQVRAHAEDLAKLVTEVCA