Protein Info for GFF4690 in Variovorax sp. SCN45

Annotation: Cobalt/zinc/cadmium efflux RND transporter, transmembrane protein CzcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1070 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 346 to 363 (18 residues), see Phobius details amino acids 368 to 387 (20 residues), see Phobius details amino acids 395 to 414 (20 residues), see Phobius details amino acids 452 to 471 (20 residues), see Phobius details amino acids 482 to 508 (27 residues), see Phobius details amino acids 529 to 555 (27 residues), see Phobius details amino acids 883 to 902 (20 residues), see Phobius details amino acids 909 to 928 (20 residues), see Phobius details amino acids 934 to 959 (26 residues), see Phobius details amino acids 983 to 1002 (20 residues), see Phobius details amino acids 1012 to 1035 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1051 (1051 residues), 1743.9 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1038 (1034 residues), 1173.3 bits, see alignment E=0

Best Hits

Swiss-Prot: 77% identical to CZCA_ALCSC: Cation efflux system protein CzcA (czcA) from Alcaligenes sp. (strain CT14)

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 82% identity to ajs:Ajs_1849)

MetaCyc: 73% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1070 amino acids)

>GFF4690 Cobalt/zinc/cadmium efflux RND transporter, transmembrane protein CzcA (Variovorax sp. SCN45)
MFERIIRFSIEQRWLILLAVLGMAALGIFSYQKLPIDAVPDITNVQVQINTAAPGYSPLE
TEQRVTYPIETVMAGLPGLQQTRSLSRYGLSQVTVIFKDGTDIYFARQLVNERIQSARES
MPRGISPVIGPISTGLGEIYLWTVEAEEGARKADGKPYSSTDLREIQDWIIKPQLRNVAG
VTEINSIGGYAKEFQISPDPAKLLAHGLTMTDLVTALERNNANVGAGYIEKRGEQYLIRA
PGQVKSVEDIGNVILGNANGIPLRVQDVAEVGIGKELRTGAATDNGREVVLGTVFMLIGE
NSRTVSQAVDRKMQEINRTLPAGVKAVTVYDRTVLVDKAIATVKKNLFEGAVLVIAILFL
FLGNIRAALITALVIPLSMLFTFTGMVNQKVSANLMSLGALDFGIIIDGAVVIVENCVRR
LAHAQAHKGRPLTRSERFHEVFAASQEARRPLLFGQLIIMIVYLPIFALTGVEGKLFHPM
AFTVVIALLGAMILSITFIPAAVALFIGNKVSEKENRLMVWAKRGYEPLLARVMGAKPLV
ITTAVVAVLLSGLLATRLGTEFVPSLSEGDFAIQALRIPGTSLTQSVEMQKQLERTLKEK
FPEIERIFARTGTAEIASDPMPPNISDGYIMLKPESEWPKPRRSRAEVLAAVQEEVEKLP
GNNYEFSQPIQLRFNELISGVRSDVAVKIFGDDMDVLNKTAAEVSEALGKIAGAAEVKVE
QTTGLPMLTVNIDRNKTARYGLNVGDVQEAISIAVGGREAGTLFDGDRRFDIIVRLPENL
RTDLEAIKRLPVALPKGAGAEGARTSFIPLGEVATLDIAPGPNQVSREDGKRRIVVSANV
RGRDLGSFVAEAEEAMRNVKIPTGYWTVWGGQYENLASATQRLQVVVPVSLLLVFTLLFA
MFGNLKDGLLVFTGIPFALTGGIVALWMRGIPLSISAAVGFIALSGVAVLNGLVMISFIR
NLREGGLPLDAAIREGALTRLRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGI
LSSTALTLLVLPLLYRIAHRRDEEEAQQEDTREQNHGAPLAPAPQGTHGT