Protein Info for GFF463 in Variovorax sp. SCN45

Annotation: Malonyl-CoA decarboxylase (EC 4.1.1.9)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 488 PF17408: MCD_N" amino acids 112 to 199 (88 residues), 84.2 bits, see alignment E=5.9e-28 PF05292: MCD" amino acids 202 to 458 (257 residues), 349.3 bits, see alignment E=1.5e-108

Best Hits

KEGG orthology group: K01578, malonyl-CoA decarboxylase [EC: 4.1.1.9] (inferred from 94% identity to vpe:Varpa_3394)

Predicted SEED Role

"Malonyl-CoA decarboxylase (EC 4.1.1.9)" (EC 4.1.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (488 amino acids)

>GFF463 Malonyl-CoA decarboxylase (EC 4.1.1.9) (Variovorax sp. SCN45)
MSATEWFQARLRSGEGSKVPVALESTARSAPKNAPKPSARSTAERLQVTLRKADEALSPR
ALRRVLAELQAVIDPRVSEVEGGRRAHAIAVAYAAAKPEERRDYWALMSEHFAADAQKLK
TARDQHQAAVGTPDEGQAELRLRRALVSPRMRLLQRFAVEPEGMRFLVDLRADLLPCLKA
DKRLIALDAELEHLFSTWFDVAFLELRRIDWDSPASLIEKLIRYEAVHDIKSWSDVKNRL
DDSDRRCYGFFHPRLPNEPLIFVEVALVDRISDGITPLLDEAAVPVLPAKATTAIFYSIS
NTQNGLRGVSFGDSLIKRVVETLQDELPRLKTFATLSPIPGFRTWLAKNAAELLPRLDEK
REAELGRLVGSLPPTAERLLAAVDAATSFEPKSPLRQWLMQAAAEYLGRALVDGTPADPV
ARFHLGNGARVERLNWAGDPSPKGQKQSYGLMVNYLYDLKRLDKHRTWLADGKVAVSGDI
ESLFFKKG