Protein Info for GFF4628 in Xanthobacter sp. DMC5

Annotation: Copper-exporting P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 742 transmembrane" amino acids 100 to 125 (26 residues), see Phobius details amino acids 137 to 158 (22 residues), see Phobius details amino acids 170 to 192 (23 residues), see Phobius details amino acids 198 to 216 (19 residues), see Phobius details amino acids 354 to 375 (22 residues), see Phobius details amino acids 381 to 403 (23 residues), see Phobius details amino acids 673 to 691 (19 residues), see Phobius details amino acids 695 to 713 (19 residues), see Phobius details PF00403: HMA" amino acids 23 to 81 (59 residues), 34.1 bits, see alignment 4.4e-12 TIGR01511: copper-translocating P-type ATPase" amino acids 153 to 714 (562 residues), 492.1 bits, see alignment E=5e-151 TIGR01525: heavy metal translocating P-type ATPase" amino acids 172 to 714 (543 residues), 470.1 bits, see alignment E=2.4e-144 TIGR01512: cadmium-translocating P-type ATPase" amino acids 195 to 716 (522 residues), 328.7 bits, see alignment E=1.3e-101 TIGR01494: HAD ATPase, P-type, family IC" amino acids 211 to 446 (236 residues), 99.5 bits, see alignment E=3.2e-32 amino acids 532 to 696 (165 residues), 99.8 bits, see alignment E=2.6e-32 PF00122: E1-E2_ATPase" amino acids 237 to 413 (177 residues), 154 bits, see alignment E=5e-49 PF00702: Hydrolase" amino acids 430 to 626 (197 residues), 105.4 bits, see alignment E=7.8e-34

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 88% identity to xau:Xaut_0465)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (742 amino acids)

>GFF4628 Copper-exporting P-type ATPase (Xanthobacter sp. DMC5)
MSEAIDYSIFVGTSEDGLAQMSLAIDGIDCAACIGEIENGVKALPGVVRARLNYSTHRLT
VAWSEGTSPDRVVGQLEALGYRAHPFAGRAEESEARHARWLLRCLGVAGFAAMNIMLLSV
SVWSGNVTDITPETRDFFHWISALIALPAAAYAGQPFFQSAVRAIRSGRLNMDVPITIGV
TLALGMSVVETAMSQPHAYFDSAIMLLFFLLAGRYLDHEARRRTRATAGNIAALRGEMAH
RIGADGVPVLVPVQALQPGDTILIHPGERVAADGVVASGLSAVDESLVTGETLPRALKAG
DHVYAGSLNGEGALHLTVTAGGENTLVDDVQRLLDGALAEKGAYVRLADRVARLYAPMVH
LTALVSAIGWLLAGAGLHDAVMIAVAVLIITCPCALALAVPAVQVTATGRLFRAGLLINA
GDMLERLAAVDTVVFDKTGTLTLPEPALALPRGADPELVALAGRLALSSRHSLAGVIAAR
AKGPALEHVTEVSGQGIEAIIDGRRARLGSLSFCEAIAPADLPADASLIAFRHGEKVLVM
GVAQALRPDAREVVAELKARGLDVRILSGDRPAAVAPVAEALGIVAAEAGLKPADKIAAL
DALKAEGRRVLMVGDGLNDAPALAAATVSLSPASGAAVTQAHADAVFLGRRLWPVLAAVD
GARTAARLMRQNLAIAVGYNIIAVPLAIAGFVTPLVAALAMSGSSILVTVNALRAARPGR
KEEAVGDDGATGEAAALTEVAA