Protein Info for PS417_23645 in Pseudomonas simiae WCS417

Annotation: amino acid permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 transmembrane" amino acids 28 to 49 (22 residues), see Phobius details amino acids 56 to 76 (21 residues), see Phobius details amino acids 104 to 129 (26 residues), see Phobius details amino acids 135 to 153 (19 residues), see Phobius details amino acids 164 to 183 (20 residues), see Phobius details amino acids 208 to 230 (23 residues), see Phobius details amino acids 248 to 268 (21 residues), see Phobius details amino acids 286 to 311 (26 residues), see Phobius details amino acids 338 to 360 (23 residues), see Phobius details amino acids 366 to 389 (24 residues), see Phobius details amino acids 409 to 429 (21 residues), see Phobius details amino acids 435 to 455 (21 residues), see Phobius details PF00324: AA_permease" amino acids 27 to 452 (426 residues), 327.5 bits, see alignment E=1.4e-101 PF13520: AA_permease_2" amino acids 28 to 452 (425 residues), 130.1 bits, see alignment E=1.1e-41

Best Hits

Swiss-Prot: 39% identical to YTNA_BACSU: Uncharacterized amino acid permease YtnA (ytnA) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 98% identity to pfs:PFLU5187)

MetaCyc: 38% identical to aromatic amino acid:H+ symporter AroP (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-56; TRANS-RXN-76; TRANS-RXN-77

Predicted SEED Role

"Phenylalanine-specific permease" in subsystem Aromatic amino acid degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UHB1 at UniProt or InterPro

Protein Sequence (468 amino acids)

>PS417_23645 amino acid permease (Pseudomonas simiae WCS417)
MTTPDNGFAEITHRELGLRRQLTSGQMSMIAIGGAIGTGLFMGSAYAIGYAGPSVLVSYA
IGALITLLLMGCLAEMTVAHSTSGSFGAYAEFYISPLAGFLVRYAYWAAIVLAVGAEVTA
VAMYMKYWFANVPEWVWIVSFSSVLILLNAISVKTFGNFEYWFSTIKISAIVGFIILAVY
VVFGSGNPQYGVQNYTAHDGFFPHGLSGMWIAVIVSIFSYLSVEMIAVAAGEAADPEQAV
KKAFRATIVRLVVFYLLTLALMLAIVPWNQAGQAQSPFVTVMQTIGIPGATGVMNFVILI
AALSAMNSQLYITTRMMFSLSRAGFAPKSMGALSKNGIPLNALLLSSSGIALATLLNVVY
PESSFTLMMAISMFGAIFTWFMIFLTHLFFRRYRKRHGGPTLSFQLRLFPYSTLLGLVLM
GAVMVTTYFTEAFKMTLVFGVPFLLILSAVYYGFFRKGRAKASNKALA