Protein Info for GFF4606 in Sphingobium sp. HT1-2

Annotation: Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 458 PF00355: Rieske" amino acids 41 to 123 (83 residues), 49.8 bits, see alignment E=2.6e-17 PF00848: Ring_hydroxyl_A" amino acids 191 to 450 (260 residues), 77.4 bits, see alignment E=1.5e-25

Best Hits

KEGG orthology group: None (inferred from 53% identity to mmi:MMAR_0307)

Predicted SEED Role

"Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit" in subsystem Phenylpropanoid compound degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (458 amino acids)

>GFF4606 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit (Sphingobium sp. HT1-2)
MSKIDNIDVEALAKPLTYPTEAFLSKDYALAEKEKLWPHVWQMAARVEELPDVGDWMTYD
ICDESIIIVRTAPDTLRAFFNVCPHRGRQLVDVPKDVHSVRGKNRRSFVCGFHGWTFDTE
GNNTYVLDPQDWQGALNAECTRLSDVKIDIWGGWIWIHMDLNAEPLIDFLGDAGRILSHF
EMDKMRYKWRKWVVYPANWKTALEAFMEPYHVAGTHTQLLDYGDYYAYSAAYGLHGVSGF
DQRDPAFQMSQSSSVTRAGKGDDPRRSTYELIRENYETLNYAASTETLVNAASRLVDELP
EGTAAGDVIAHWLKSAKADDAARGVIWPEIPPEVMAEAGLAWHVFPNMSVLQGITFALCY
RTRPYGDDPDMCIFESYAIERFPEGEVPATEWEETEATAEGWGAVLAQDFSNMEWVQKGM
KSRGFRGPLPNPHQERKITNFHRNLATYMGTGAPRLLK