Protein Info for GFF46 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Intramembrane protease RasP/YluC, implicated in cell division based on FtsL cleavage

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 transmembrane" amino acids 6 to 29 (24 residues), see Phobius details amino acids 55 to 72 (18 residues), see Phobius details amino acids 98 to 122 (25 residues), see Phobius details amino acids 376 to 398 (23 residues), see Phobius details amino acids 426 to 445 (20 residues), see Phobius details TIGR00054: RIP metalloprotease RseP" amino acids 3 to 450 (448 residues), 571.7 bits, see alignment E=4.6e-176 PF02163: Peptidase_M50" amino acids 10 to 438 (429 residues), 265.4 bits, see alignment E=8.6e-83 PF00595: PDZ" amino acids 209 to 276 (68 residues), 40 bits, see alignment E=1e-13 PF13180: PDZ_2" amino acids 212 to 287 (76 residues), 32.9 bits, see alignment E=1.6e-11 PF17820: PDZ_6" amino acids 227 to 278 (52 residues), 39.7 bits, see alignment 8.1e-14

Best Hits

Swiss-Prot: 100% identical to RSEP_SALT1: Regulator of sigma-E protease RseP (rsep) from Salmonella typhimurium (strain 14028s / SGSC 2262)

KEGG orthology group: K11749, regulator of sigma E protease [EC: 3.4.24.-] (inferred from 100% identity to sed:SeD_A0245)

MetaCyc: 88% identical to intramembrane zinc metalloprotease RseP (Escherichia coli K-12 substr. MG1655)
3.4.21.-; RXN-18678

Predicted SEED Role

No annotation

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (450 amino acids)

>GFF46 Intramembrane protease RasP/YluC, implicated in cell division based on FtsL cleavage (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MLSILWNLAAFIIALGVLITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDRYGTEYV
IALIPLGGYVKMLDERAEPVAPELRRHAFNNKTVGQRAAIIAAGPVANFIFAIFAYWLVF
IIGVPGVRPVIGEITPNSIAAQAQIAPGTELKAVDGIETPDWDAVRLQLVSKIGDQQTTV
SVAPFGSDQRQDKTLDLRHWAFEPDKQDPVSSLGIRPRGPQIEPVLSEVQANSAASKAGL
QAGDRIVKVDGQPLTQWMKFVTFVRDNPGKPLALEIERQGSALSLTLTPDTKSVNGKAEG
FAGVVPKIIPLPEEYKTIRQYGPFSAILEATDKTWQLMKLTVSMLGKLITGDVKLNNLSG
PISIAQGAGMSAEFGVIYYLMFLALISVNLGIINLFPLPVLDGGHLLFLAIEKLKGGPVS
ERVQDFSYRIGSILLVLLMGLALFNDFSRL