Protein Info for GFF4583 in Sphingobium sp. HT1-2

Annotation: Cobalt/zinc/cadmium resistance protein CzcD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 207 transmembrane" amino acids 16 to 37 (22 residues), see Phobius details amino acids 43 to 64 (22 residues), see Phobius details amino acids 75 to 94 (20 residues), see Phobius details amino acids 104 to 126 (23 residues), see Phobius details amino acids 147 to 164 (18 residues), see Phobius details amino acids 170 to 188 (19 residues), see Phobius details PF01545: Cation_efflux" amino acids 17 to 194 (178 residues), 63.7 bits, see alignment E=1.1e-21

Best Hits

KEGG orthology group: None (inferred from 77% identity to sch:Sphch_4097)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcD" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (207 amino acids)

>GFF4583 Cobalt/zinc/cadmium resistance protein CzcD (Sphingobium sp. HT1-2)
MDEATSGVNQRLERNTLWIVLILNVLISAAFFIVGFTGDSSALIANGVDNLSDALVYALS
LVALSRGVTWKSRAAMFSGSMLLVFAVGILIDVGRRYVYGSEPIGTAMMAMSAVAAIVNF
ICLRLLQRLEQPDVNMRAATTFSFNDFISNGGILIAGVLVWWLGTNWPDLLVGVATALIA
IKGGVEILKDARSEIREAKGRPEIKEA