Protein Info for GFF4582 in Xanthobacter sp. DMC5

Annotation: Coenzyme A biosynthesis bifunctional protein CoaBC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00521: phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase
  • amino acids 2 to 396 (395 residues), 408.3 bits, E=1.7e-126
• PF02441: Flavoprotein
  • amino acids 5 to 177 (173 residues), 113.9 bits, E=6e-37
• PF04127: DFP
  • amino acids 188 to 372 (185 residues), 232.9 bits, E=2.6e-73

Best Hits

Swiss-Prot: 47% identical to COABC_ALIF1: Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC) from Aliivibrio fischeri (strain ATCC 700601 / ES114)

KEGG orthology group: K13038, phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase [EC: 4.1.1.36 6.3.2.5] (inferred from 88% identity to xau:Xaut_0078)

Predicted SEED Role

"Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) / Phosphopantothenoylcysteine synthetase (EC 6.3.2.5)" in subsystem Coenzyme A Biosynthesis (EC 4.1.1.36, EC 6.3.2.5)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis I (bacteria) (9/9 steps found)
• superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
• coenzyme A biosynthesis I (bacteria) (4/4 steps found)
• coenzyme A biosynthesis II (eukaryotic) (4/4 steps found)
• coenzyme A biosynthesis III (archaea) (3/4 steps found)
• taurine biosynthesis II (1/4 steps found)

KEGG Metabolic Maps

• Pantothenate and CoA biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.36 or 6.3.2.5

Protein Sequence (405 amino acids)

>GFF4582 Coenzyme A biosynthesis bifunctional protein CoaBC (Xanthobacter sp. DMC5)
MLKDKRILLLIGGGIAAYKCLDLARRLKERGATVRAIMTEAAGRFVTPLSVGAITGERVF
TDLFDLTAEHDIGHIRLSREADLLVVAPATADLLARMAHGLADDLATTCLLATDKPVLVA
PAMNPRMWSHPATRRNVAQLKADGVSVVGPNSGAMAERGEFGEGRMAEPMEILAAIEAHF
DDGAARLLAGRRILVTSGPTHEPIDPVRFIANRSSGKQGHAIAAAARAAGAEVVLVSGPA
EAADPAGVRVIHVESARDMLAAVEENLPVDAAVFAAAVADWRVADASEQKIKKDGGGAPT
LTLVENPDILASVSRHHTLRPRLVVGFAAETEQVVAHARDKRLRKGCDWIVANDVSPATG
IMGGDSNTVHLVTAAGVEDWPSATKAEVARHLVARIAAELSGTHP