Protein Info for GFF4575 in Sphingobium sp. HT1-2

Annotation: GGDEF domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 415 transmembrane" amino acids 6 to 29 (24 residues), see Phobius details amino acids 39 to 58 (20 residues), see Phobius details amino acids 64 to 82 (19 residues), see Phobius details amino acids 94 to 111 (18 residues), see Phobius details amino acids 120 to 143 (24 residues), see Phobius details amino acids 163 to 183 (21 residues), see Phobius details amino acids 192 to 212 (21 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 222 to 384 (163 residues), 132.3 bits, see alignment E=7.2e-43 PF00990: GGDEF" amino acids 225 to 381 (157 residues), 133.1 bits, see alignment E=4.2e-43

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (415 amino acids)

>GFF4575 GGDEF domain protein (Sphingobium sp. HT1-2)
MNLSMPIDAVTMLLMTQAIALVAALVLAAEWRLAKVRSLAWWSAGFATIVVGSGMSVLRT
ADSFLLYVWLANGLLVVAHLLFAKGAAAFAGRRLPGIWLGVLLVWVALLGTDPASDRTAL
FGLVNSALVAILSLKAASLLLSLRRTSEVRDAVRLGHIFLGHGIFYLAKSGLIFMPGLFV
SLVGFKGLLIKASLYEGILVEVSLALLMLAAVRHRRERQITALAERDSLTGAYNRRAFEA
KAAAGMALARRTGQPVALLLCDVDHFKAVNDGFGHATGDRLLSGLAAILTDCVPADALVA
RLGGDEFAVLLFGLPPENLPALGRRICHRFAQSGAGVAGASLQVSTSIGAATSITGTEEL
PHLFDRADRALYDAKRKGRDRMSVESGVDLSVATPPLRLAKVARRACVGCQEVCS