Protein Info for PS417_23405 in Pseudomonas simiae WCS417

Annotation: transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 507 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details PF13185: GAF_2" amino acids 25 to 159 (135 residues), 29.4 bits, see alignment E=3.5e-10 PF01590: GAF" amino acids 25 to 159 (135 residues), 47.6 bits, see alignment E=1e-15 PF00158: Sigma54_activat" amino acids 187 to 353 (167 residues), 232.4 bits, see alignment E=1e-72 PF14532: Sigma54_activ_2" amino acids 188 to 358 (171 residues), 74.9 bits, see alignment E=3.2e-24 PF00004: AAA" amino acids 211 to 333 (123 residues), 25.3 bits, see alignment E=7.2e-09 PF07728: AAA_5" amino acids 211 to 329 (119 residues), 32.9 bits, see alignment E=2.4e-11 PF02954: HTH_8" amino acids 465 to 499 (35 residues), 26.6 bits, see alignment 1.6e-09

Best Hits

Swiss-Prot: 51% identical to NORR_VIBVY: Anaerobic nitric oxide reductase transcription regulator NorR (norR) from Vibrio vulnificus (strain YJ016)

KEGG orthology group: K12266, anaerobic nitric oxide reductase transcription regulator (inferred from 94% identity to pfs:PFLU5143)

Predicted SEED Role

"Functional role page for Anaerobic nitric oxide reductase transcription regulator NorR" in subsystem Nitrosative stress

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See U1SZI9 at UniProt or InterPro

Protein Sequence (507 amino acids)

>PS417_23405 transcriptional regulator (Pseudomonas simiae WCS417)
MTAQSLLTTLLPLVADLSRELPEGERYRRLLQAMRALLPCDAAALLRLDGEWLVPLAVDG
LSADTLGRRFKVSEHPRFAVLLSSPGPTRFDSDSELPDPYDGLVDGLHGHLEVHDCMGCP
LFVDDQPWGLLTLDALDTERFERVELDALQAFASLAAATVNVAERIERLTLRAEIYREAS
GQQHKEMIGQSKPHKRLVEEIKLVGGSDLTVLITGETGVGKELVAQAIHAASTRADKPLI
SLNCAALPETLVESELFGHVRGAFTGALNERRGKFELANGGTLFLDEVGELSLTVQAKLL
RVLQSGQLQRLGSDKEHQVDVRLIAATNRDLADEVRNGRYRADFYHRLSVYPLQVPALRE
RGRDVLLLAGFFLEQNRSRMGLGSLRLTSDAQAALLAYNWPGNVRELEHLIGRSALKALG
NCRERPKILSLNAQDLDLPDVSAPLIEEQTGSAPVVTGDLRQATEQYQRQVISACLERHQ
HNWASAARELGLDRANLGRMAKRLGLK