Protein Info for GFF4534 in Variovorax sp. SCN45

Annotation: Tetrapartite efflux system, outer membrane factor lipoprotein FusA-like

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 492 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details TIGR01845: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family" amino acids 15 to 472 (458 residues), 274.8 bits, see alignment E=6.6e-86 PF02321: OEP" amino acids 70 to 261 (192 residues), 71.5 bits, see alignment E=4.2e-24 amino acids 292 to 463 (172 residues), 78.6 bits, see alignment E=2.8e-26

Best Hits

KEGG orthology group: None (inferred from 85% identity to vpe:Varpa_0912)

Predicted SEED Role

"Outer membrane component of tripartite multidrug resistance system" in subsystem Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (492 amino acids)

>GFF4534 Tetrapartite efflux system, outer membrane factor lipoprotein FusA-like (Variovorax sp. SCN45)
MNDMTSFAFRLASLAAAAALAACAAVGPDYRQPPEALASQSAAGKPFAEAPANAAPLPPH
WWRLYHDPLLDKLVEQALAHNTDLRQAVANLERERAIEDEVAGAKYPSIGVNGGPSYGHV
SGLSLLQKGYEPPNTFNYSAGASLSYQVDLFGQIRRAIEASQASTQAAEAALDLVRVNVA
AGTARAYAEACSTGLRLRIAQKSVSLQQDAVNVTDRLQRAGRAGAIDAGRARAQLQQLNA
ALPPLKAERQGALYRLATLTGALPQDFPREVADCSEPPRVAGTLPVGDGAALLRRRPDIR
QAERSLAASTARIGVATADLYPKITLGLSGSSVGHADGFGRKDTFAWSLGPLISWTVPNT
GVVQSHIAQAEAGTRAALAKFDGTVLTALRETETALATYARELDRRAALQASRDESAKVA
AQARQLYQNGRTGYLDSLDAERSLAASEAALAASEAQLSDDQIVLFMALGGGWEPADTNL
AQGAAAATTVKQ