Protein Info for GFF4517 in Xanthobacter sp. DMC5

Annotation: Sensor histidine kinase RcsC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 890 PF01627: Hpt" amino acids 3 to 95 (93 residues), 54.5 bits, see alignment E=2.9e-18 PF02895: H-kinase_dim" amino acids 210 to 268 (59 residues), 46.6 bits, see alignment 9.5e-16 PF02518: HATPase_c" amino acids 317 to 456 (140 residues), 63.2 bits, see alignment E=7.7e-21 PF01584: CheW" amino acids 462 to 599 (138 residues), 89.3 bits, see alignment E=4.6e-29 amino acids 627 to 745 (119 residues), 40.1 bits, see alignment E=6.8e-14 PF00072: Response_reg" amino acids 769 to 879 (111 residues), 60.2 bits, see alignment E=5.3e-20

Best Hits

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (890 amino acids)

>GFF4517 Sensor histidine kinase RcsC (Xanthobacter sp. DMC5)
MDDLLREFLTETSESLDVADVELVKFEQDPNNAQILNNIFRLVHTIKGTCGFIGLPRLAS
LAHAAETLMDRFREGRPVTTDAVGLVLSTIDRIKLLLQHVEETEGSEPEGEDRDLISLLE
AMAEAVDAPAAPPPPAPPPQPAQTLERPLLPGELPLDELDRIFRETKVDPLPPAPAPAAP
PKPAPAMPKADADATHAAAQAGEAHGVAAQSIRVHVGVLEQLMTMVSELVLTRNQLMEIA
RRHDEPEYKVSLQRLSNVTGELQEAVMRTRMQPIGNAWQKLPRIVRDLAQELGKQIELEQ
VGADTELDRQVLDQIKDPLTHMVRNSADHGLEMPEQRRAAGKSERGLIRLSAYHEGGHVI
VEISDDGRGLDVARIKQKALENGLATEAELAKMPDSQVFRFIFHAGFSTAQKVTNVSGRG
VGMDVVRSNLESIGGTVDVRSRQGEGSTFVIKIPLTLAIVPALIVRAAGERFALPQSAVE
ELVRVQAGSDHEITWLNNSPVLGLRDRLLPIVSLGALLGLSPERDGRDEALWERALIVVM
KVGHQTFGVVVEAVSHTEEIVVKPMASALRQLPMVSGSTILGDGRVIMILDPAGLAQHAA
ARGGAAEEVSHHGAGRQSRASQKRSSLLLFRAGSRDLKAVPLGLVTRIEELEVARIERVN
GYPVLQYRGALIPVLYANEEVQRVAAGTQPMLVFADGGRVMGLVVDEIVDIVEAELDMEL
SPSNMPEVLGAAVLSGQATEILDVAFYVQVAFGERFRHLVRSSERPRLLLVDESPFHRDL
LAPMLNGNGYEVTACASGGEALARLGTEDGFDAIVSDVDLPDMDGFALAAAVRGDPRIRE
VPIIALATAQDRDALERGRAVGFTDCVAKFDRSGLIAALKEFTGRQGIAA