Protein Info for GFF4484 in Sphingobium sp. HT1-2

Annotation: Multicopper oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 631 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details TIGR01480: copper-resistance protein, CopA family" amino acids 3 to 625 (623 residues), 822.6 bits, see alignment E=9.2e-252 PF07732: Cu-oxidase_3" amino acids 58 to 165 (108 residues), 117.3 bits, see alignment E=6.5e-38 PF00394: Cu-oxidase" amino acids 240 to 332 (93 residues), 84.4 bits, see alignment E=1.5e-27 PF07731: Cu-oxidase_2" amino acids 508 to 626 (119 residues), 109 bits, see alignment E=2.5e-35

Best Hits

KEGG orthology group: None (inferred from 72% identity to sch:Sphch_4184)

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (631 amino acids)

>GFF4484 Multicopper oxidase (Sphingobium sp. HT1-2)
MSPGLNRRDLFRGAALAGGGLALSAWLPAWAQPISSGIAKPLPTVSGNDITLKIAHQMMM
IDGRQSHAIGINGTVPAPLIRLRQGQNVRLSVINDLEEDSSIHWHGLLLPFQFDGVPGIS
FPGIKPKSTFVYEFPIVQAGTYWYHSHSGLQEQLGHYGPIVIDPEGEDPIQSDREHVIVL
SDHSQMHPHAIFRKLKQVGGGYFNYQRQTLAGLLAKEDQPLKDRLDWGNMRMDPTDVSDV
TGSTYTYLVNGHGPRDNWTALFKPGERVRLRFVNASAMTTFNVRIPGLKLTVVQADGLNV
RPVEVDEFQIAVAETYDVIVTPTDDRAYTLVGESVDRSGMARATLAPREGMTAEVPPLRK
RPLADMKDMGMGDMDMSGMSGMDHAAMGHDMSAGGAAAGGMAGMDMGAGASMPSMQKPAD
SSMANMPGMGSGSGDTMGGMAMGGMGGMNMRDASKAPQVKMGPGVQTISPMPMDRTGEPG
QGLEDVGHRVLVYRDLMAVERNPDVRAPDRAMEIHLTGNMERYMWSFDGVKLSDKREPIP
FIENERVRVTLVNDTMMSHPIHLHGHFFELVTGHGEYSPRKHTVNVAPGGKVSFDVTADA
VGDWAFHCHMLYHMHAGMMRVVSVRPRGDAA