Protein Info for GFF4471 in Sphingobium sp. HT1-2

Annotation: Transcriptional regulator, MerR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 159 PF13411: MerR_1" amino acids 4 to 71 (68 residues), 70.3 bits, see alignment E=1.8e-23 PF00376: MerR" amino acids 5 to 42 (38 residues), 53 bits, see alignment 3.5e-18 PF09278: MerR-DNA-bind" amino acids 47 to 110 (64 residues), 54.1 bits, see alignment E=3e-18

Best Hits

Swiss-Prot: 37% identical to MERR_SHIFL: Mercuric resistance operon regulatory protein (merR) from Shigella flexneri

KEGG orthology group: K13638, MerR family transcriptional regulator, Zn(II)-responsive regulator of zntA (inferred from 98% identity to sjp:SJA_C1-05190)

Predicted SEED Role

"transcriptional regulator, MerR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (159 amino acids)

>GFF4471 Transcriptional regulator, MerR family (Sphingobium sp. HT1-2)
MGNFKIGELAAAAGVGRDTIRYYERMGLLREPARTAAGYRLYDATDLERVNFIRSAQELG
FTLEQARQLLALRASDTAHAQAVLDITLAKIADAEARLERLSDIRDMLRMLADECPGEVP
VSDCPILAFLTARRKDQQHNKKHQAAQDERSSLAKGLLS