Protein Info for GFF4454 in Sphingobium sp. HT1-2

Annotation: Multicopper oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 568 signal peptide" amino acids 1 to 36 (36 residues), see Phobius details TIGR01480: copper-resistance protein, CopA family" amino acids 7 to 567 (561 residues), 796.7 bits, see alignment E=6.4e-244 PF07732: Cu-oxidase_3" amino acids 55 to 163 (109 residues), 124 bits, see alignment E=7e-40 PF00394: Cu-oxidase" amino acids 239 to 334 (96 residues), 61.4 bits, see alignment E=2.4e-20 PF07731: Cu-oxidase_2" amino acids 451 to 567 (117 residues), 97.6 bits, see alignment E=1.1e-31

Best Hits

KEGG orthology group: None (inferred from 98% identity to sch:Sphch_4196)

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (568 amino acids)

>GFF4454 Multicopper oxidase (Sphingobium sp. HT1-2)
MSPLHIRPIARRRFVQGLAIGGAVAGFAPALLARSAPVSPAELSGTEFDLEIAELPVNFT
GKRRIATAVNGSVPAPVLRLREGDTVTLRVRNGLKEMSSIHWHGIIVPAEMDGVPGISFA
GIAPGETFTYRFEVRQSGTYWYHAHTLAEQTGLYGAIIVEPKQAPTARAPDRDYCIVLSD
WSDEPPLQIFLNLKKQSSYYNFAQPTAGDFLKDAGAMGLGRALERRRMWNSSRMNPTDYS
DVSAATYTYLMNGAPPAGNWTGIAAPGERVRLRFVGAGTATFFDVRIPGVELTVVSTDGQ
PVEPVTVEEFRIGPGETYDVEFTMPEGGARTIFAQAIDRSGYARGTIAPAPGMAAAVPPL
DARTWLEPVDMMGAMATMGAMGGDAHAGHGMIEMPARAQHARTEYGANTDMRVDYPRTNL
DDPGAGLRGRDWRVLTLADLRTPGGDPDPREPERDIELHLTGNMERFIWSLDGLKLNDSR
PLHFRPNERLRVTFVNDTMMAHPMHLHGMWSDVEGPDGAFQVRKHTVVVQPAQRVSFRVT
ADALGRWAFHCHLLYHMAAGMFREVVVA