Protein Info for GFF4433 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Ureidoglycolate dehydrogenase (EC 1.1.1.154)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 349 transmembrane" amino acids 225 to 245 (21 residues), see Phobius details TIGR03175: ureidoglycolate dehydrogenase" amino acids 1 to 349 (349 residues), 695.7 bits, see alignment E=5.9e-214 PF02615: Ldh_2" amino acids 3 to 331 (329 residues), 373 bits, see alignment E=6.8e-116

Best Hits

Swiss-Prot: 87% identical to ALLD_ECO57: Ureidoglycolate dehydrogenase (NAD(+)) (allD) from Escherichia coli O157:H7

KEGG orthology group: K00073, ureidoglycolate dehydrogenase [EC: 1.1.1.154] (inferred from 99% identity to sec:SC0567)

MetaCyc: 87% identical to ureidoglycolate dehydrogenase (Escherichia coli K-12 substr. MG1655)
RXN0-7024 [EC: 1.1.1.350]

Predicted SEED Role

"Ureidoglycolate dehydrogenase (EC 1.1.1.154)" in subsystem Allantoin Utilization (EC 1.1.1.154)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.154 or 1.1.1.350

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (349 amino acids)

>GFF4433 Ureidoglycolate dehydrogenase (EC 1.1.1.154) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKISRETLHQLIENKLYKAGLKREHAAIVADVLVYADARGIHSHGAVRVEYYAERISKGG
TNREPTFRIENTGPCTAILHADNAAGQVAAKMGMEHAIEIAKKNGVAVVGISRMGHSGAI
SYFVRQAAREGLIGLSICQSDPMVVPFGGADIYYGTNPLAFAAPGEGDDIITFDMATTVQ
AWGKVLDARSRNESIPESWAVDKNGAPTHDPFAVNALLPAAGPKGYGLMMMIDILSGILL
GLPFGRQVSSMYEDLHAGRNLGQLHLVINPAFFSSCELFRKHISQTMQELNAVKPAPGFK
QVYYPGQDQDIKQKNADMNGIDIVDDIYQYLISDALYLKSYETKNPFAQ