Protein Info for GFF440 in Variovorax sp. SCN45

Annotation: CobN-like chelatase BtuS for metalloporphyrine salvage

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1337 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 1309 to 1328 (20 residues), see Phobius details PF02514: CobN-Mg_chel" amino acids 145 to 1218 (1074 residues), 967.8 bits, see alignment E=4e-295

Best Hits

KEGG orthology group: K02230, cobaltochelatase CobN [EC: 6.6.1.2] (inferred from 84% identity to vpe:Varpa_3369)

Predicted SEED Role

"CobN component of cobalt chelatase involved in B12 biosynthesis" in subsystem Coenzyme B12 biosynthesis

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.6.1.2

Use Curated BLAST to search for 6.6.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1337 amino acids)

>GFF440 CobN-like chelatase BtuS for metalloporphyrine salvage (Variovorax sp. SCN45)
VTRVFLRWLLGLLAALGLLASVHAQPAGGRVVVLSTPLVSPARVVRLEAAAREAGLPLQV
VSASKDSPETLAAALEDARLLVIDAPHISVAQAAAARFGDVISRGAVPYVLVGEFALVAK
GQASAAAPLAAERGVDAAWAQRLREYWRFAGTANLAASMQAMAKPGELAGLPAPVPLPLA
GFYHPGWPRIETDIAALDRLPGNPASGTVAIAINSATVTGDDTGWLDALIASLEQRSLRA
YAFYGPRQQKDLFFGMTHAGERRVADLIVNASLVFSPNERKAELERIGVPVLQTLPSLAM
DATQWAQSKDGLSQTDIASYYSPSELAGMTDPMLVSARDAASGTLQPLPAQIDAVAAKAA
ALLRLQRTPASQRRVAMLVYNYPPGEANFGASFLNVPRSVNNMLAAMKSAGYDTDLPGTD
ALIAQVQATMKAYYPTGQDDALQPLLDRGLAEAMPLPRYLTWFRTLPEATQRRIEAYWGP
PEKSAMLRPVAGEPVFVIPRVRFGNVVVLRQPPRFEPGTQVVDKAGQVYHRSAVPLSHGY
LATYLWLRTQFGASAVVHVGTHGTVEWSAGKERGLSVQDDPLLALADLPNVYPYIMDNLG
EATTAKRRGRATMVSHSTPMFAPAGFRPGVQAMHERMHDWENLSPGPVKTAMERQLTAEF
AEQHYDRDLQWTPARIRADFAGFIAVLHPYLDELAQTAQPLGLATFGQAPDAERRRMTIL
QILGKPLVEALGEDIDEAFLIDAKSVAASKPARWVELALSDAAAASAMGKTPADVQKLGE
LAERARKLDAVLSHNEEIEGLLTALDGRYLKASYGGDPVRNPDSLPTGRNLYGFDPSRVP
TRAAWETGVAAMDAWIAAHAKSHAGKAPEKIAFTLWAGEASRHQGVLESQAFHAMGVKPR
WDDAGRMSGIEVIPAKALGRARMDVLISVTGSYRDQFPNVMRWLDEAVRQVAALPEPGNA
VAQHSEALAGKLRAQGATPEEARRWATARVFSNEQGSYGAGLEEAALASDAWKSQQRGGG
DAQMAQLYMDRMGHAYGKGLDGASRPGAYAGNLAQVDAALMARSSNLYGVLTNDDPFQYL
GGIAQAVRQLTGKDPALYVQNLRDGPAVRTDTAAGAIAREMQTRYLHPQWIAAQKAEGYS
GTLQVLKTAQFLWGWQVTAPDVVRQDQWQSLHDVYVRDRYKLGTREWLEGDNRAAFAQTL
ERMLDAVRLNYWKPDAATRRELARAYVEAAGATGLRERNEGVQRFVRQQLAAPTVHAATV
APVIAAPPPAEPAKAPEAEPAADGARPVSGLRLEPTPDKLPAPKAESVVLQLWVVFGAAL
LAALGALVQWRRGRAAA