Protein Info for GFF4391 in Xanthobacter sp. DMC5

Annotation: Cyclohexadienyl dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03807: F420_oxidored
  • amino acids 8 to 96 (89 residues), 36.7 bits, E=1.3e-12
• PF03446: NAD_binding_2
  • amino acids 9 to 130 (122 residues), 24.7 bits, E=5.3e-09
• PF02254: TrkA_N
  • amino acids 10 to 62 (53 residues), 26.3 bits, 2e-09
• PF02153: PDH_N
  • amino acids 21 to 175 (155 residues), 121.5 bits, E=5.6e-39
• PF20463: PDH_C
  • amino acids 179 to 279 (101 residues), 100.2 bits, E=1.9e-32

Best Hits

Swiss-Prot: 42% identical to TYRC_ZYMMO: Cyclohexadienyl dehydrogenase (tyrC) from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)

KEGG orthology group: K00220, cyclohexadieny/prephenate dehydrogenase [EC: 1.3.1.12 1.3.1.43] (inferred from 88% identity to xau:Xaut_0393)

Predicted SEED Role

"Cyclohexadienyl dehydrogenase (EC 1.3.1.12)(EC 1.3.1.43)" in subsystem Chorismate Synthesis or Phenylalanine and Tyrosine Branches from Chorismate (EC 1.3.1.12, EC 1.3.1.43)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• L-tyrosine biosynthesis I (3/3 steps found)
• L-tyrosine biosynthesis III (3/4 steps found)
• superpathway of chorismate metabolism (41/59 steps found)
• 4-hydroxy-3-prenylbenzoate biosynthesis (1/4 steps found)
• superpathway of novobiocin biosynthesis (4/19 steps found)

KEGG Metabolic Maps

• Novobiocin biosynthesis
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.1.12 or 1.3.1.43

Protein Sequence (313 amino acids)

>GFF4391 Cyclohexadienyl dehydrogenase (Xanthobacter sp. DMC5)
VIQPLVPRLAIIGAGLIGSSLARAAREKHLTGTLVVADSDPAVCERVRQLGFADVVTVDA
AEAAEGSDIVVVAVPVGASGKVAEVVGPRLKAGAILSDVGSVKGFVVEAMAPHVPAHAHL
IPAHPVAGTEFSGPDAGFASLFENRWCIVTPPEGADPEAVARIVALWRAAGANVETMSAQ
HHDLVLAITSHVPHLIAYNIVGTAAHLEETLTSEVIKFSAGGFRDFTRIASSDPTMWRDV
FLTNRDAVLEMLGRFTEDLTALQRAIRYGDGDVLFEHFARTRAIRRSIIEQGQETAAPDF
GRRAAEKPKHEDS