Protein Info for GFF4383 in Xanthobacter sp. DMC5

Annotation: L-threonine 3-dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 500 1000 1500 2000 2500 3080 PF00109: ketoacyl-synt" amino acids 30 to 277 (248 residues), 291.8 bits, see alignment E=3.8e-90 PF02801: Ketoacyl-synt_C" amino acids 286 to 403 (118 residues), 139.4 bits, see alignment (E = 4.1e-44) PF16197: KAsynt_C_assoc" amino acids 405 to 498 (94 residues), 39.9 bits, see alignment (E = 3.8e-13) PF00698: Acyl_transf_1" amino acids 574 to 888 (315 residues), 179.9 bits, see alignment E=6.7e-56 PF21089: PKS_DH_N" amino acids 940 to 1028 (89 residues), 56.5 bits, see alignment (E = 1.7e-18) PF14765: PS-DH" amino acids 1074 to 1226 (153 residues), 53.8 bits, see alignment 1.3e-17 PF08240: ADH_N" amino acids 1496 to 1582 (87 residues), 40.4 bits, see alignment (E = 2.2e-13) PF00107: ADH_zinc_N" amino acids 1623 to 1729 (107 residues), 72.8 bits, see alignment (E = 2e-23) PF13602: ADH_zinc_N_2" amino acids 1655 to 1794 (140 residues), 61.1 bits, see alignment 1.7e-19 PF08659: KR" amino acids 1817 to 1997 (181 residues), 177.1 bits, see alignment 2.5e-55 PF00106: adh_short" amino acids 1820 to 1977 (158 residues), 52.3 bits, see alignment 3.8e-17 PF13561: adh_short_C2" amino acids 1826 to 1977 (152 residues), 38.8 bits, see alignment 6.2e-13 PF23297: DUF7080" amino acids 2094 to 2172 (79 residues), 34 bits, see alignment (E = 1.9e-11) PF00550: PP-binding" amino acids 2096 to 2159 (64 residues), 49.6 bits, see alignment (E = 3e-16) PF00668: Condensation" amino acids 2626 to 2955 (330 residues), 84.4 bits, see alignment E=5.7e-27

Best Hits

Predicted SEED Role

"Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 2.3.1.39)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.39

Use Curated BLAST to search for 2.3.1.39

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (3080 amino acids)

>GFF4383 L-threonine 3-dehydrogenase (Xanthobacter sp. DMC5)
MDSVDLLDGELKAVISHSLSETQATETLAVAVVGIGCRFPGGIASGSDYWSFLVGKRCGI
REIPADRWNYRNYYDPDPECAGRSYSKWGGFLTGDVFSFDPAFFDMAPREVMSMDPQQRL
LLQVAFETVEDSGITLRTLQKKRTGVFVGISTSDFSYSQRYRRVATDIFAGTGSAYSIAA
NRISHRLDLTGPSIALDTACSSALVAVDQAIRHLSMGTCDVALAGGVNMMLDPGPFVAFS
SANMLSATGAIYTFDARADGFVRGEGCGLVLLKPLARAVADGDRIYGVLRGSTVNQDGRT
PTLTAPSDVAQTAMLNSLLEQTGIDPEDVGYVEAHGTGTPVGDPIEASAIGRVFGAGRVD
RPVLVGSFKPNLGHLESASGIAGLIKIVLSAHHGVVPPNLNFERPNPNIPFDALGLKVPV
EPTPYDAEDGVRLSVVNSFGFGGTNASVAVESWHGGGRAAKAAPARAVPSDDPAFIPLSA
NGKPALALWAEELAEAVDMGGALSGVSYDSLSQVLKTSRDHLSERAVLLADRAAQDLPHK
LRMLALGADAPAEEAEAVAPYIITGRARPRRLAFTFSGQGGQWWAMGRKLLTTEPTYRAF
VEEFDAVLKPWTGWSVVEEVLKAEDKTRINDADVTQASIFTMQVGLYRMWRERGLTPELL
VGHSFGEVATTYIAGCIDLETCAKIIYHRGLIPHGSSRRGAMATLGVTFDQLAPLLPDDG
SVVVAAYNGPTAQTISGMEAPVDAVLAEVRRLFPDVTARRLTMDFGWHSPHLDDCEAKFR
EGLGEIDWKPPSIPIVSTVTAMLETRFDSEYWWQNLRQPVNYKKAIDFCLDLGIDAFLEL
GPHRTVTPLIHGIAQERNASVVAVPSLERQGDDRLVMARSMANLYVNGVAFDWTEAAKDG
EADAPARPEHLALPRRPWVTERLVQLPLEARQFLFDTDRHPLLGWRESGPEPAWTNEITL
KSLKYLADHRPGGDCLFPTVGYVEMMAAALRELFGAAPVELRDFKIMEALSIGSDDVVLL
RTSYDPVTSRLRISSLKRDTEEDWRLRVEAYGWQHAFTLPKATFDPAVLSGTPAITREDF
YRLTARHGLDYGPSFQAVEALWLPGPRHAVARIVSAEAARRTGFVAFPGLFDSVLQAGLV
VDDVEAGLWIPGEPLPEMDEVGGKYRLMLPVGIRKVMVAGPLPSEVICEFFTDPRDDTGI
YRVYATDGTPLLAVENLQVKTLGALKASTGEGAVVIDETYESDADKAPAPLRTGRWLLVT
GDAAETAPLAAALEVQGSTVETMDPAPLFAMEADVFTAQVEAMLAAPEGLAGILYAATIG
THLADADALSTPALLAAVEPAANGLVTVGKALDRLRTAPLRPTLVVLGRAGRRVPGDGAM
TTDGLADAPLLGLTRTIANECPEFAVRHVDADAAAFAAGATLAQAVAEESAEAEIVLRGV
GRLVPRLRQSELAAQAPKHRVIAADTDRSNFTVTMTQPGVIDNVVLRACPYPTPKAGEVV
VEVAAVGLNFRDIMAATSILPDEQDGAGAWWRNLGLEFAGTIQMVGEGVTGFSPGDRVMG
MGKGFLRRFAAADARFLMHVPDHVDLKDAATLPAAFMTAHYALVDIGRLLPEEQVLVHLA
TGGVGLAAIQVARNIGAGILASAGSDAKRDHLRALGITCVMNSRSLEFAEDVRAATSGRG
VDVVLNALSGAGIDKGLECLAPFGRFVEIGKRDLAQDKPIGLKSLYYNNSYSVIDLSTIA
DERPARLSSLLRAVEAEVARGAYRPLVATRFPVSRAADAMRLFAKAQHIGKVVLTFDEPE
VEVEIDLAQPMQLSAEASYLVTGGLRGFGVAVADYLSKAGAGRLLLAGRNGTPDEDAAPV
IAAIEVRGTQVVPLALDVTDPEAVEAVIAAHAASDKPLKGIVHGAAVIEDGFLAQLDAAQ
ISRVIRPKVGGGWSLHRAVAKHGVALDFFVSFSSLAQVIGSPGQANYTAANAFLNALGSF
RKGRGVAGSSVAWGSIAGSGFVSRSEALGNYLESIGMKPVPDTEAAASLGTLLRAEGENP
AFARADWSAIARALARTAATGRVKPLLAQRSAGRSRIQADLLAAPREQWDAMLADLIRGE
VAKVLKVAAADIPPDRRLSELGLDSLSSFELKNRIEAHVDVNIPVAKFLQTPTITGLSGV
VAATFEAAQKARAASAEALAAGGEGAGGSAGPLTFRPLVRQEAMLALATRPMTTQAVRSA
LEVAASRPVPTGLAFEPLARALADLAAAQDALRLTATETGAIVLNGAPDLEWVTSAEALA
PVTQPGPLWRFGVSKGEDGTLTLHARAHRAAADALSPHLALAALIAAVETAPTPGAPFTA
FAAEGRPADGSPEQGRHLAFWKEVLRAAPPALATGVRSLALAPAGFGINRGPVGRISARI
AMPGFAALPATEQEALLLSAFARTLATRHGATALAIECHDPARRDGLLGPVSTSVPLLLD
RLCEADRLVRRTRQRLAMARDHRAIDTAALEAILGAKLNAAGAALRQLGFSYLDAASASA
LAALGIADPLAALADPFNELRLDALAEGDGVRLVLALDTAAFDAGGGKAFIDAFATTLEA
LGGSAASVCDATWHAPAEPLRRSAAAVPEPVAAASAPVHVSGEREVPLSLKQGLLLRSFL
KPETGHACRSAWTVNRAFRITPRMDLERLRRALRLVEERQEALRSRFVLGDDGRPRVFIL
PPGEPPLVVEDMPEAGGDVDARIAALMDDEMDPFTNPPYRITVLRCGPEGDVVVAHGHHT
VFDGWSLGLFVEELFQAFLGIPLPPPEMDVATYVNTFERATDPAFMAERDAYLRSLYAVD
PPPVPHFGRRAKGLTPNFDLTQGGPSGEMFAFLSADGQQRLQARARAAGVTETALLIAAV
AQTVAARGGVDDVMLNVPAAMRTDRRLNGFISWVAGSALLRAPARALPKLETLAASLADQ
LNRAMPYVPFEYAALDGAVHDEVIAAGSYLALYQTGMQAPDRFARGATTSTLQRQGKSEV
LDLGHIKVAPVSSRLMRYAINEFDLRSFQSTDGLAYRLGFDLTALTPAEGRGLLEEVLDR
MELGGEGCTAIVDADEEQPA