Protein Info for GFF437 in Sphingobium sp. HT1-2
Annotation: Succinylglutamic semialdehyde dehydrogenase (EC 1.2.1.71)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 66% identical to ASTD2_CAUVC: N-succinylglutamate 5-semialdehyde dehydrogenase 2 (astD2) from Caulobacter vibrioides (strain ATCC 19089 / CB15)
KEGG orthology group: K06447, succinylglutamic semialdehyde dehydrogenase [EC: 1.2.1.71] (inferred from 67% identity to swi:Swit_0529)MetaCyc: 55% identical to aldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Succinylglutamate-semialdehyde dehydrogenase. [EC: 1.2.1.71]
Predicted SEED Role
"Succinylglutamic semialdehyde dehydrogenase (EC 1.2.1.71)" in subsystem Arginine and Ornithine Degradation (EC 1.2.1.71)
MetaCyc Pathways
- L-arginine degradation II (AST pathway) (4/5 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.71
Use Curated BLAST to search for 1.2.1.71
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (470 amino acids)
>GFF437 Succinylglutamic semialdehyde dehydrogenase (EC 1.2.1.71) (Sphingobium sp. HT1-2) MIFRSIDPASDTLLWEGDAADAATCAAAVVRARAAFPAWAALPQSEREDHVRRYKALLSD RSDAFAKAIARETGKPLWEAKTEIASMIGKVDISIAAQAERAGSREQATPFGRAVLRHKP HGVMAVLGPYNFPGHLPNGHIVPALLAGDVVIFKPSELTPLVGELMAQAFRDAGLPDGVF TLLQGGRDTGAALIAQDIDGLLFTGSAAAGAHFTRVMADRPGVILALELGGNNPLVAWDG DAQAVASIIVQSAFITAGQRCSCARRLILPQGAAGDAILDATVALARRLTIGAWDSQPEP YMGALISAEAAAHAKARQAALLARGGVELLPLEQPANLGAAFLTPGIIDMTGVDAPDEEI FAPLLQVARVADFDAAIAAANATRYGLAAGLVSADDALWDRFLLESRAGVVNRNRPTTGA SGAMPFGGLGASGNHRPSAYYAADYCAYPVASFEAEEVLDLTADIKGLAG